| 醇脱氢酶结构和作用机理研究进展 |
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| 引用本文： | 许松伟,姜忠义,吴洪.醇脱氢酶结构和作用机理研究进展[J].有机化学,2005,25(6):629-633. |
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| 作者姓名： | 许松伟 姜忠义 吴洪 |
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| 作者单位： | 天津大学化工学院,天津,300072 |
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| 基金项目： | 国家自然科学基金，天津市应用基础研究项目，教育部跨世纪优秀人才培养计划 |
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| 摘 要： | 介绍了醇脱氢酶的种类, 酵母醇脱氢酶和肝醇脱氢酶等两类常用的醇脱氢酶的物理化学性质和活性位点结构. 归纳了对肝醇脱氢酶和酵母醇脱氢酶作用机理的研究, 重点评述了醇脱氢酶催化反应中的两个关键步骤质子转移和氢化物转移过程机理的研究进展.
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| 关 键 词： | 醇脱氢酶 烟酰胺腺嘌呤二核苷酸 机理 氢化物 质子 |
| 收稿时间： | 2004-5-24 |
| 修稿时间： | 2004年5月24日 |
Progress in Structure and Kinetic Mechanism of Alcohol Dehydro-genase |
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| XU,Song-Wei,JIANG,Zhong-Yi,WU,Hong.Progress in Structure and Kinetic Mechanism of Alcohol Dehydro-genase[J].Chinese Journal of Organic Chemistry,2005,25(6):629-633. |
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| Authors: | XU Song-Wei JIANG Zhong-Yi WU Hong |
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| Affiliation: | (School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072) |
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| Abstract: | The type of alcohol dehydrogenases, the chemical and physical properties and structure of active site of two common types of alcohol dehydrogenase, yeast alcohol dehydrogenase (YADH) and liver alcohol dehydrogenase (LADH) were introduced. Research progress in the kinetic mechanism of YADH and LADH was summarized with special focus on the progress in the proton transfer and hydride transfer, two key steps involved in the dehydrogenase-catalyzed reaction. |
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| Keywords: | alcohol dehydrogenase nicotinamide adenine dinucleotide mechanism hydride proton |
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