Targeted Delivery of DNA‐Au Nanoparticles across the Blood–Brain Barrier Using Focused Ultrasound |
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| Authors: | Tiffany G. Chan Sophie V. Morse Matthew J. Copping Dr. James J. Choi Prof. Ramon Vilar |
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| Affiliation: | 1. Department of Chemistry, Imperial College London, London, UK;2. Centre of Excellence in Neurotechnology, Imperial College London, London, UK;3. Department of Bioengineering, Imperial College London, London, UK |
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| Abstract: | Nanoparticles have been widely studied as versatile platforms for in vivo imaging and therapy. However, their use to image and/or treat the brain is limited, as they are often unable to cross the blood–brain barrier (BBB). To overcome this problem, herein we report the use of focused ultrasound in vivo to successfully deliver DNA‐coated gold nanoparticles to specific locations in the brains of mice. |
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| Keywords: | blood– brain barrier brain DNA nanoparticles ultrasound |
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