| 布洛芬-壳聚糖缓释微囊药代动力学研究 |
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| 引用本文： | 王艰,李柱来,许秀枝,严文锦,蚩会丽.布洛芬-壳聚糖缓释微囊药代动力学研究[J].海峡药学,2010,22(12):268-270. |
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| 作者姓名： | 王艰 李柱来 许秀枝 严文锦 蚩会丽 |
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| 作者单位： | 福建医科大学药学院,福州,350004 |
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| 摘 要： | 目的研究自制布洛芬壳-聚糖微囊的药代动力学。方法以市售布洛芬普通片剂为参比通过高效液相色谱测定模型动物家兔药时曲线。结果相对于普通片剂,兔口服布洛芬-壳聚糖微囊后,达峰时间明显推迟,且达峰浓度降低（P〈0.05）;同时药物在兔体内平均驻留时间明显长于普通片（P〈0.05）;但两制剂的AUC无差异（P〉0.05）。结论研制的布洛芬-壳聚糖微囊具有较好的缓释效果,且吸收程度与普通布洛芬片剂等效。
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| 关 键 词： | 壳聚糖 布洛芬 微囊 药代动力学 |
Study on Pharmacokinetics of ibuprofen-Chitosan Microcapsules |
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| WANG Jian,LI Zhu-lai,XU Xiu-zhi,YAN Wen-jin,CHI Hui-li.Study on Pharmacokinetics of ibuprofen-Chitosan Microcapsules[J].Strait Pharmaceutical Journal,2010,22(12):268-270. |
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| Authors: | WANG Jian LI Zhu-lai XU Xiu-zhi YAN Wen-jin CHI Hui-li |
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| Affiliation: | (Faculty of Pharmacy,Fujian medical university,Fuzhou 350004,China) |
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| Abstract: | OBJECTIVE To study the pharmacokinetics of ibuprofen-chitosan microcapsules.METHODS Taking conventional ibuprofen tablets as control,and high preformance liquid chromatography（HPLC）was used to determine drug concentrationtime curve in rabbits.RESULTS Compared with the conventional tablets,the sustained-release ibuprofen-chitosan microcapsules have longer action time in rabbits,and the peak time was obviously delayed,the peak concentration was decreased.but the AUC of them was not different statistically（P0.05）.CONCLUSION The prepared ibuprofen-chitosan microcapsules has a better sustained drug release effect,and the absorption degree of them was equivalet. |
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| Keywords: | Chitosan Ibuprofen Microcapsules Pharmacokinetics |
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