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| C-反应蛋白基因多态性与代谢综合征的关联研究 | |
| 引用本文： | 金岳龙,贺连平,陈金凤,王彬彬,沈冲,姚应水.C-反应蛋白基因多态性与代谢综合征的关联研究[J].中国临床药理学与治疗学,2011,16(12):1391-1396. |
| 作者姓名： | 金岳龙 贺连平 陈金凤 王彬彬 沈冲 姚应水 |
| 作者单位： | 1. 皖南医学院预防医学系,芜湖241002,安徽 2. 南京医科大学公共卫生学院流行病与卫生统计学系,南京210029,江苏 3. 南京医科大学第一临床医学院,南京210029,江苏 |
| 基金项目： | 国家自然科学基金(81072367); 安徽省自然科学基金(090413126) |
| 摘 要： | 目的:探讨C-反应蛋白(C-reaction protein,CRP)基因rs6677719位点多态性与代谢综合症(metabolism syndrome,MS)的关系.方法:研究对象来自从某乡镇6个村整群抽样调查人群,纳入301例MS对象作为病例组,同时选取年龄和性别与病例匹配的547例健康个体作为对照组,所有的研究对象完成了问卷调查、体格检查及临床生化指标检测.采用聚合酶链反应-限制性片段多态性(PCR-RFLP)方法完成CRP基因rs6677719位点基因分型,比较不同基因型在病例组和对照组中的分布差异,及其与血糖、血压和血脂等指标的关系.结果:关联分析结果表明,rs6677719位点变异与MS存在显著关联,相加模型和显性模型均有统计学意义,OR值(95％可信区间)分别为0.785(0.640～0.862)和0.659(0.489～0.889).对照组TC基因型TG水平显著低于TT基因型(P＜0.05),而高密度脂蛋白(HDL-C)和低密度脂蛋白(LDL-C)水平在TT、TC和CC基因型间存在显著线性关系(P＜0.05).结论:CRP基因rs6677719位点变异与MS存在显著关联,并影响人体TG、HDL-C和LDL-C代谢. |
| 关 键 词： | 代谢综合征 C-反应蛋白 关联研究 |
Association of polymorphism in CRP gene with metabolic syndrome |
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| JIN Yue-long , HE Lian-ping , CHEN Jin-feng , WANG Bin-bin , SHEN Chong , YAO Ying-shui.Association of polymorphism in CRP gene with metabolic syndrome[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(12):1391-1396. | |
| Authors: | JIN Yue-long HE Lian-ping CHEN Jin-feng WANG Bin-bin SHEN Chong YAO Ying-shui |
| Affiliation: | JIN Yue-long1,HE Lian-ping1,CHEN Jin-feng2,WANG Bin-bin3,SHEN Chong2,YAO Ying-shui1 1 Department of Preventive Medicine,Wannan Medical College,Wuhu 241002,Anhui,China,2 Department of Epidemiology & Statistics,School of Public Health,Nanjing Medical University,Nanjing 210029,Jiangsu,3 The First Clinical Medical College |
| Abstract: | AIM: To investigate the association of rs6677719 polymorphism in the C-reactive protein gene with metabolic syndrome.METHODS: Stratified cluster sampling method was conducted to select 301 cases of metabolic syndrome and 547 healthy individuals who were matched with cases for age and gender from a community based population.Questionnaire was managed,and physical examination and blood biomarkers tests were conducted,and rs6677719 locus was detected by the method of polymerase chain reaction-restriction fragm... |
| Keywords: | Metabolic syndrome C-reactive protein Association study |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
