| CD4^＋CD25^＋调节性T细胞在肿瘤免疫中的作用研究 |
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| 引用本文： | 刘立,吴文川,刘保池.CD4^＋CD25^＋调节性T细胞在肿瘤免疫中的作用研究[J].国外医学(外科学分册),2011(4):259-262. |
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| 作者姓名： | 刘立 吴文川 刘保池 |
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| 作者单位： | [1]郑州大学第一附属医院急诊科,郑州450052 [2]复旦大学附属中山医院普外科,上海200032 |
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| 基金项目： | 国家自然科学基金（No.30801104） |
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| 摘 要： | CD4^＋CD25^＋调节性T细胞（Treg）在自身免疫耐受、免疫自稳、肿瘤免疫中发挥着重要作用,它可以抑制自身抗原或者非自身抗原如肿瘤抗原引起的免疫反应.人们对Treg细胞的免疫抑制作用已进行了相关的研究和临床应用,最新研究表明其能够诱导肿瘤特异性抗原和局部的免疫反应.此综述将讨论Treg细胞的相关表面分子及其在肿瘤免疫逃逸机制、肿瘤免疫治疗中的研究进展.
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| 关 键 词： | CD4^＋CD25^＋调节性T细胞 肿瘤免疫 免疫反应 |
Mechanisms of CD4^＋CD25^＋ regulatory T-cell suppression in tumor immunity |
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| Affiliation: | LIU Li , WU Wen- chuan , LIU Bao- chi (Department of Emergency, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China) |
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| Abstract: | CD4^＋CD25^＋ regulatory T- cell （Treg） play essential roles in maintaining self- tolerance, immune homeostasis and cancer immune system. Treg can suppress immune responses against self antigens or non-selfantigens such as tumor antigens. The immunosuppressive functions of Treg are widely acknowledged and have been extensively studied. Recent studies demonstrate the existence of Treg at tumor sites, implying that these Treg may induce antigen-specific and local immune tolerance. This review will discuss the ligands, mechanisms of immune suppression of Treg and its potential roles in cancer therapy. |
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| Keywords: | CD4^＋CD25^＋ Treg Tumor immunity Immune response |
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