长期运动训练对慢性心力衰竭患者心肌型脂肪酸结合蛋白的影响

目的:评价长期中等强度运动训练对慢性心力衰竭(CHF)病人血浆心型脂肪酸结合蛋白(H-FABP)的影响。方法:采用药物标准治疗的60例CHF病人被随机分为两组:运动训练组(30例),常规治疗组(30例),另设正常对照组(30例)。于治疗前、后抽血检测血清脑钠肽(BNP)及H-FABP水平,并进行比较分析。结果:CHF患者运动训练组及常规治疗组治疗前血清BNP(357±32)mg/ml,(343±14)mg/ml:(36±4)mg/ml]、H-FABP(15.5±3.1)μg/ml,(13.0±5.4)μg/ml:(4.1±2.3)μg/ml]水平均显著高于正常对照组(P均0.05);与治疗前比较,运动组运动训练6个月后BNP(357±32)mg/ml:(104±41)mg/ml],H-FABP(15.5±3.1)μg/ml:(6.1±4)μg/ml]明显下降(P0.01),常规治疗组治疗后BNP(343±14)mg/ml:(165±20)mg/ml],H-FABP(13.0±5.4)μg/ml:(8.2±5.1)μg/ml]也有明显下降(P0.05),但运动组疗效优于常规治疗组(P0.05)。血清H-FABP、BNP水平随心衰加重而明显升高(P0.05),H-FABP与BNP呈正相关(r=0.39,P0.05)结论:长期适当的运动训练,可使慢性心力衰竭病人血浆心型脂肪酸结合蛋白的水平显著下降。

Effects of long-term exercise training on blood level of heart type fatty acid binding protein in patients with chronic heart failure

Objective：To evaluate the effects of long-term moderate intensity exercise training on blood level of heart type fatty acid binding protein（H-FABP） in patients with chronic heart failure（CHF）.Methods：A total of 60 CHF patients undergoing standard medical treatment were randomly assigned to two groups：exercise group（groupⅠ,n=30） and conventional treatment group（groupⅡ n=30）.And a normal control group was set.Brain natriuretic peptide（BNP） and H-FABP were measured in all patients before and after treatment.Results：Before treatment,serum BNP and H-FABP levels of groupⅠand group Ⅱ were significantly higher than those of normal control group.Compared with before treatment,serum levels of BNP and H-FABP of groupⅠ significantly decreased after exercise training six-month,so was groupⅡ after treatment.And the therapeutic effect of groupⅠwas significantly better than that of group Ⅱ（P〈0.05）.Serum levels of BNP and H-FABP significantly increased as heart failure got worse（P〈0.05）.And level of H-FABP was positively related with that of BNP（r=0.39,P〈0.05）.Conclusion：Long-term moderate exercise training could decrease blood level of heart type fatty acid binding protein in patients with chronic heart failure.