| 噁三唑类NO供体型他汀衍生物的合成及活性评价 |
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| 引用本文： | 陈宇瑛,薛雨,艾林,曾其炀. 噁三唑类NO供体型他汀衍生物的合成及活性评价[J]. 中国抗生素杂志, 2020, 45(1): 42-48 |
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| 作者姓名： | 陈宇瑛 薛雨 艾林 曾其炀 |
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| 作者单位： | 抗生素研究与再评价四川省重点实验室;四川抗菌素工业研究所金华分所;浙江海森药业股份有限公司 |
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| 基金项目： | 成都市科技项目(No.2016-XT00-00023-GX) |
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| 摘 要： | 目标 合成系列噁三唑类NO供体型他汀衍生物并进行体外活性评价。方法 选用噁三唑类NO供体分别与阿托伐他汀和辛伐他汀通过酯化进行偶联。结果 设计合成了5个噁三唑类NO供体和5个该类NO供体型他汀衍生物。结论 通过部分目标化合物体外活性测定，表明它们具有良好的NO释放活性。
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| 关 键 词： | 他汀 噁三唑 合成 NO释放 |
Synthesis and activity assay of novel oxatriazole NO donator-type statin derivatives |
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| Chen Yu-ying,Xue Yu,Ai Lin,Zeng Qi-yang. Synthesis and activity assay of novel oxatriazole NO donator-type statin derivatives[J]. Chinese Journal of Antibiotics, 2020, 45(1): 42-48 |
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| Authors: | Chen Yu-ying Xue Yu Ai Lin Zeng Qi-yang |
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| Affiliation: | (Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province,Sichuan Industrial Institute of Antibiotics,Chengdu University,Chengdu 610052;Jinhua Branch of Sichuan Industrial Institute of Antibiotics,Jinhua 321000;Zhejiang Haisen Pharmaceutical Co.,Ltd.,Jinhua 322104) |
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| Abstract: | Objective To synthesize a series of novel oxatriazole NO-donating statin derivatives and evaluate their NO release activities in vitro. Methods We used esterification reaction to couple oxatriazole NO-donors and two statins, respectively. Results Five oxatriazole NO-donors and five oxatriazole NO-donating statin derivatives were designed and synthesized. Conclusion The target compounds showed good NO release activity in |
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| Keywords: | Statin Oxatriazole Synthesis NO release |
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