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| 自发性高血压大鼠血红素氧合酶的基因表达 | |
| 引用本文： | 鹿克风,郭玲,王克平,刘继东,张良惠,王延军. 自发性高血压大鼠血红素氧合酶的基因表达[J]. 现代中西医结合杂志, 2001, 10(15): 1419-1420 |
| 作者姓名： | 鹿克风 郭玲 王克平 刘继东 张良惠 王延军 |
| 作者单位： | 1. 山东省立医院心内科,济南市,250021 2. 山东省立医院研究生,济南市,250021 3. 山东省立医院中心实验室,济南市,250021 |
| 摘 要： | 目的 :探讨高血压时血红素氧合酶 -一氧化碳系统的状态。方法 :选取自发性高血压大鼠 (SH R)及与之相匹配的正常血压大鼠 (WKY)各 8只 ,应用 RT-PCR技术检测主动脉血管平滑肌细胞血红素氧合酶基因表达。结果 :SHR的血管平滑肌细胞血红素氧合酶基因表达较 WKY明显降低。结论 :血红素氧合酶基因表达降低在高血压的发病中可能具有重要作用 |
| 关 键 词： | 高血压 血红素氧合酶 一氧化碳 |
Gene expression of heme oxygenase of spontaneous hypertensive rats |
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| Lu Kefeng,Guo Ling,Wang Keping Cardiology Department,Shandong Provincal Hospital,Jinan Liu Jidong,Zhang Lianghui Student of Shandong Provincal Hospital,Jinan Wang Yanjun Central Laboratory,Shandong Provincal Hospital,Jinan. Gene expression of heme oxygenase of spontaneous hypertensive rats[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2001, 10(15): 1419-1420 | |
| Authors: | Lu Kefeng Guo Ling Wang Keping Cardiology Department Shandong Provincal Hospital Jinan Liu Jidong Zhang Lianghui Student of Shandong Provincal Hospital Jinan Wang Yanjun Central Laboratory Shandong Provincal Hospital Jinan |
| Affiliation: | Lu Kefeng,Guo Ling,Wang Keping Cardiology Department,Shandong Provincal Hospital,Jinan 250021 Liu Jidong,Zhang Lianghui Student of Shandong Provincal Hospital,Jinan 250021 Wang Yanjun Central Laboratory,Shandong Provincal Hospital,Jinan 250021 |
| Abstract: | Objective: It is to explore the status of heme oxygenase carbon monoxide system in hypertension. Methods: Eight spontaneous hypertensive rats (SHRs) and 8 WKYs (with normal blood pressure) were selected. The HO-1 mRNA expression in aortic smooth muscle cell was measured by RT PCR. Results: HO 1mRNA expression in vascular smooth muscle cell in SHRs is lower than in WKYs. Conclusion: The lower gene expression of HO 1 may be play an important role in the mechanisms of primary hypertension. |
| Keywords: | hypertension heme oxygenase carbon monoxide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
