| FLG基因及相关疾病研究进展 |
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| 引用本文： | 李晶辉,尤家宝,刘红,张福仁. FLG基因及相关疾病研究进展[J]. 中国麻风皮肤病杂志, 2017, 0(2): 117-120 |
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| 作者姓名： | 李晶辉 尤家宝 刘红 张福仁 |
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| 作者单位： | 山东省皮肤病医院,山东大学,济南,250022;山东省皮肤病性病防治研究所,山东省医学科学院,济南,250022 |
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| 基金项目： | 山东省自然科学基金培养基金(编号:ZR2015PH040)山东省自然科学基金联合基金(ZR2014YL037) |
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| 摘 要： | 丝聚蛋白(filaggrin,FLG)基因位于人类染色体1q21.3,其翻译表达产物与维持皮肤屏障和细胞分化功能密切相关。研究发现FLG基因的多态性与特应性皮炎、银屑病、寻常型鱼鳞病等多种疾病发病相关,本文对近年关于FLG基因及与其相关疾病的研究进行了综述。
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| 关 键 词： | FLG 特应性皮炎 银屑病 寻常型鱼鳞病 |
Update of FLG gene and related diseases |
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| LI Jinghui,YOU Jiabao,LIU Hong,ZHANG Furen. Update of FLG gene and related diseases[J]. China Journal of Leprosy and Skin Diseases, 2017, 0(2): 117-120 |
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| Authors: | LI Jinghui YOU Jiabao LIU Hong ZHANG Furen |
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| Abstract: | Filaggrin gene (FLG), which encodes profilaggrin, is located on human chromosome1q21.3. FLG is associated with the epidermal barrier and the cell differentiation. The polymorphism of FLG gene is closely associated with atopic dermatitis, psoriasis, ichthyosis vulgaris as well as other diseases. The FLG gene and related diseases were reviewed in this article. |
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| Keywords: | FLG atopic dermatitis psoriasis ichthyosis vulgaris |
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