三氧化二砷对视网膜色素上皮细胞增殖的影响

视网膜色素上皮细胞(retinal pigment epithelial cell,RPE)在维护视网膜正常生理功能方面具有极其重要的作用。研究发现,视网膜色素上皮细胞是增殖性玻璃体视网膜疾病(proliferative vitreous retinopathy,PVR)发生发展的主要细胞,而其增殖与细胞内调控信息失调密切相关。多项研究成果表明,三氧化二砷(As2O3)已经被用于医药几千年。其在白血病治疗的使用早在一个世纪以前就有所描述。As2O3在医学上的作用有着悠久的历史。然而,在最近的几个世纪它几乎被遗忘在西方医学。三氧化二砷在白血病、肿瘤的基础研究与临床治疗中已取得较大进展,引起广泛关注,但在眼科领域的研究才刚刚起步.增殖性视网膜疾病的发病日趋严重,已经成为全球性的重大负担,此病所导致的眼部并发症严重影响患者视功能及生活质量,因此,有必要就三氧化二砷对视网膜色素上皮细胞增殖的作用进行综述,以期为眼科疾病的防治研工作提供新的思路和策略。

Arsenic Trioxide Effects on Retinal Pigment Epithelial Cell Proliferation

Retinal pigment epithelial cells (RPE) have an extremely vital role in maintaining normal retinal physiologicalfunction. Researches have found that retinal pigment epithelial cells are the main cells for the development of proliferative vitreousretinopathy (PVR). Anumber of studies have demonstrated that arsenic trioxide (As2O3) has been applied in medicine for thousands ofyears. Its use in leukemia treatment are described as early as a century ago. However, in recent centuries, it is almost forgotten inwestern medicine. Although the basic and clinical research on arsenic trioxide in leukemia and cancer has made great progress and getextensive attention, the research in the eye field has just started. Hyperplastic diseases of retina disease has become increasinglyserious. It has become a major global burden. The ocular complications it caused seriously affect the patient''s visual function and qualityof life. Therefore, it is necessary to review the proliferation role of arsenic trioxide on the retinal pigment epithelial cell so as to providenew ideas and strategies for the prevention and control of the eye disease.