Severe hypoglycaemia in a person with insulin autoimmune syndrome accompanied by insulin receptor anomaly type B. |
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| Authors: | T Kato M Itoh J Hanashita T Itoi T Matsumoto Y Ono S Imamura N Hayakawa A Suzuki Y Mizutani Y Uchigata N Oda |
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| Affiliation: | Division of Endocrinology and Metabolism, Department of Internal Medicine, Fukita Health University, School of Medicine, Toyoake, Aichi, Japan. |
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| Abstract: | AIMS: A rare case of the insulin autoimmune syndrome (IAS) accompanied by insulin receptor anomaly is reported. METHODS: Antibodies to insulin and insulin receptor were determined in the patient with severe hypoglycaemia before and after the treatment with prednisolone. RESULTS: Titers of antibody to insulin and insulin receptors were 73.0% and 41.5%, respectively. Drug-induced lymphocyte stimulation tests were all negative for the suspicious drugs. Her HLA-DR was DRB1*0403/04051. Following steroid therapy, the formation of antibodies was suppressed and alleviated her symptoms. Scatchard analysis yielded findings specific to polyclonal antibodies. CONCLUSIONS: The changes in autoantibodies resulted in alleviation of the hypoglycemic symptoms as a result of steroid therapy. |
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| Keywords: | autoimmune hypoglycaemia insulin receptor syndrome |
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