PTTG表达与垂体腺瘤侵袭性关系

目的 探讨垂体瘤转化基因(Pituitary tumor transforming gene，PTTG)表达与腺瘤侵袭性的关系及其临床意义。方法 回顾近年我科经手术切除的44例垂体腺瘤标本及6例正常垂体组织，均经10％的福尔马林固定、石蜡包埋。联合运用Knosp影像学标准及任祖渊标准，参考术中情况，将肿瘤标本分为侵袭组与非侵袭组；运用免疫组化的方法检测这50例标本中PTTG蛋白表达情况；分析PTTG表达与垂体腺瘤侵袭性的内在关系。结果 免疫组化实验结果显示PTTG蛋白在侵袭性垂体腺瘤组中显著高表达，在非侵袭性腺瘤组中有一定表达，在正常垂体组织中未见表达。结论 原癌基因PTTG表达水平和垂体腺瘤侵袭性密切相关，可作为腺瘤侵袭性的标志物。

The relationship between invasiveness and expression of PTTG in human pituitary adenomas

Objective To explore the relationship between pituitary tumor transforming gene (PTTG) expression and invasiveness of pituitary adenomas and its clinical value. Methods A total of 44 pituitary adenoma specimens surgically removed in our department and 6 normal pituitary tissue samples were collected. All the samples were fixed with 10% formalin and then embedded with paraffin. Every case history was reviewed in detail. All the specimens were divided into invasive group(35 cases) and noninvasive group(9 cases) by the combined application of Knosp imaging diagnosis standard and Renzuyuan's standard and referring to all operation records. Expressions of PTTG protein in 50 slices of specimens were examined by immunohistochemistry. The relation between expression of PTTG protein and invasiveness of the pituitary adenomas was analyzed. Results Immunohistochemistry showed that there was significantly high PTTG protein expression in invasive group and low in noninvasive group but no expression in normal pituitary tissue. There was a significant correlation between the expression level of PTTG protein and invasiveness of the pituitary adenomas(P<0.01). Conclusion High PTTG protein expression in protooncogene is associated with the invasiveness of pituitary adenomas, suggesting PTTG can serve as the molecule marker of adenoma invasiveness.