| 复方制剂珮夫人小儿咳露中主药成分的含量测定 |
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| 引用本文： | 南楠,赵文.复方制剂珮夫人小儿咳露中主药成分的含量测定[J].中国药物依赖性杂志,2003,12(1):60-62. |
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| 作者姓名： | 南楠 赵文 |
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| 作者单位： | 中国药品生物制品检定所，中国药品生物制品检定所 北京，100050，北京，100050 |
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| 摘 要： | 目的 :建立一种采用高效液相色谱检测复方制剂中氢溴酸美沙芬、愈创木酚甘油醚和马来酸氯苯那敏含量的方法。方法 :采用C1 8色谱柱 ,以 0 .0 0 2 5mol·L- 1 IPR -B6 甲醇溶液∶水 (含 2 %三乙胺 )∶磷酸 (12 0∶10 0∶1)为流动相 ,检测波长为 2 5 7nm。结果 :氢溴酸美沙芬、愈创木酚甘油醚和马来酸氯苯那敏 3种成分的回收率分别为10 0 .5 % ,99.5 % ,10 0 .6% ;RSD分别为 2 .2 % ,1.6% ,1.9% (n =7)。结论 :本方法简便 ,结果准确可靠
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| 关 键 词： | 高效液相色谱法 氢溴酸美沙芬 愈创木酚甘油醚 马来酸氯苯那敏 |
DETERMINATION FOR THE CONTENTS OF THREE ACTIVE INGREDIENTS IN MADAME PEARL'S COUGH SYRUP FOR CHILDREN |
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| NAN Nan,ZHAO Wen.DETERMINATION FOR THE CONTENTS OF THREE ACTIVE INGREDIENTS IN MADAME PEARL''''S COUGH SYRUP FOR CHILDREN[J].Chinese Journal of Drug Dependence,2003,12(1):60-62. |
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| Authors: | NAN Nan ZHAO Wen |
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| Abstract: | Objective : A method of HPLC for the determination of complex preparations of guaiphenesin , chlorpheniramine maleate and dextromethorphan hydrobromide has been described Methods : C 18 column , 0.0025 mol·L -1 IPR-B 6 in methanol ∶ water ( containing 2% triethylamine )∶ phosphate acid (120∶100∶1) as the mobile phase were adopted The wavelength of detectionwas 257 nm. Results : The method recoveries of guaiphenesin , chlorpheniramine maleate and dextromethorphan hydrobromide were 99.5%, 100.6% and 100.5%, respectively . RSD were 1.6%, 1.9% and 2.2 ( n =7),respectively . Conclusion: The method is simple , rapid and reliable . |
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| Keywords: | HPLC guaiphenesin chlorpheniramine maleate dextromethorphan hydrobromide |
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