膦甲酸钠治疗慢性乙型肝炎疗效观察

目的:探讨膦甲酸钠(可耐)治疗慢性乙型肝炎的疗效。方法:选择1 0 0例慢性乙型肝炎患者,给予膦甲酸注射液3g/3 0 0mL ,静脉滴注,bid×1 5d后改为qd ,共3 0d ;对照组3 1例,仅给常规护肝药物、静脉滴注,共3 0d ,检测治疗前后患者血清乙肝三系,HBV -DNA及肝功能变化情况。结果:治疗后HBeAg阴转率两组分别为4 6 %、2 2 .5 8% ,HBV -DNA阴转率两组分别为6 6 %及1 9.3 5 % ,有显著性差异(P <0 .0 5 ) ,肝功能恢复亦优于对照组。HBsAg阴转方面无意义。结论:静脉注射膦甲酸钠,用于治疗慢性乙型肝炎,对抑制乙肝病毒复制及肝功能恢复具有一定作用

A Study of Efficacy of Phosphonoformate in Treatment of Chronic Hepatitis B

Objective: To study the efficacy of phosphonoformate (foscarnet sodium) in treatment of chronic hepatitis B. Methods: 100 patients with chronic hepatitis B were chosen and given phosphonoformate injection 3g/300ml ivgtt, bid×15 days, then qd, total 30 days; the control group (31 cases) were given only liver protecting drugs, ivgtt ,total 30 days. Before and after treatment, patients' blood was examined for serum HBV markers, HBV-DNA and liver function changes. Results: After treatment, the negative reactions of HBeAg in both groups were 46% ,22.58%, respectively, and the negative reactions of HBV-DNA were 66% and 19.35%, respectively, with significant difference (P<0.05). Also liver functions were recovered better in the Phosphonoformate group than that in the control group. HBsAg negative reactions had no meaning. Conclusion: Infusion of phosphonoformate in treatment of chronic hepatitis B has a definite effect on inhibition of HBV replication and recovery of liver functions.