不同来源黄芩提取物抗流感病毒作用的实验研究

目的比较不同来源黄芩提取物（河北、山西、大连）对流感病毒甲型鼠肺适应株（FM1）感染小鼠的死亡保护及抑制作用。方法以FM1感染小鼠为动物模型，感染1h后给药，以死亡率、平均存活天数、肺指数为评价指标，观察不同来源黄芩提取物在小鼠体内的抗流感病毒作用。结果不同来源黄芩提取物均能降低流感病毒感染小鼠的死亡率（P〈0．05），延长小鼠的存活时间（p〈0．05），降低肺指数（P〈0．05）。结论不同来源黄芩提取物均具有良好的抗流感病毒感染作用，其中以河北黄芩水提组效果最佳。

Experimental Study on Anti-Influenza Virus Effect of Different Sources Extracted Scutellaria

Objective To compare the effect of different sources extracted scutellaria （Hebei, Shanxi and Dalian） on the death-protection and inhibition of FM1 infected mice. Method As animal model, FM1 infected mice was treated an hour after infection. Indexes including mortality, average survival time, lung index were observed to evaluate the effect of different sources extracted scutellaria on anti-influenza virus. Result Different sources extracted scutellaria reduced mortality （P〈0.05）, prolonged the survival time of mice （P〈0.05） and decrease lung index （P〈0.05}. Conclusion Different sources extracted scutellaria have anti-influenza virus effect, and aqueous extract of Hebei scuteUaria is the best.