缺血性卒中患者颅内外血管狭窄率研究

目的:研究缺血性卒中患者颅内外血管狭窄或闭塞的发生率,并对其相关病因进行分析。方法:对经CT/MRI/DWI诊断的缺血性卒中患者的人口构成情况进行登记,了解其相关危险因素。并经TCD和/或MRA了解其颅内外血管狭窄或闭塞的情况。结果:579例缺血性卒中患者中,颅内外血管狭窄的发生率为70.98%(411/579例);411例大动脉狭窄或闭塞患者中,以大脑中动脉狭窄或闭塞最常见(64.48%),其次为颈内动脉(50.36%)。大动脉狭窄或闭塞的主要原因为动脉粥样硬化,引起动脉粥样硬化的危险因素的发病率依次为:高血压病(77.24%),吸烟(63.68%)。通过Logistic回归分析发现,糖尿病、高血压、吸烟是血管狭窄的主要相关危险因素(P值均<0.05)。结论:国内缺血性卒中患者颅内外血管狭窄或闭塞的发生率高,其主要病因为动脉粥样硬化,糖尿病是大动脉狭窄或闭塞的最主要危险因素。

Intracranial and extracranial artery stenosis study in patients with ischemic stroke

Objective: To study the occurrence of intracranial and extracranial artery stenosis in ischemic stroke patients. Methods: Ischemic stroke patients were done TCD and MRA to understand, and intracranial and extracranial arter-y stenosis or occlusion and their arteriosclerosis history, for example, hypertension, diabetes, hyperlipidemia and so on were registed. Then the correlation between artery stenosis and atherosclerosis was studied. Results: 70. 98% large-artery stenosis or occlusion were found in ischemic stroke patients, among of them, middle cerebral artery is most frequently affected vessel (64. 48%), followed by internal carotid artery. The most common pathogenesis of large-artery occlusive disease is artherosclerosis, main risk factors including hypertension (77. 24%) and smoking (63. 68%). Among of them, diabetes, hypertension and smoking in turn are associated tightly with large-artery occlusive diseases (P<0. 05). Conclusion: ischemic stroke patients in Chinese have a high occurrence of intracranial artery occlusive disease. The main pathogenesis is arteriosclerosis. Diabetes is the most important risk factor of the large-artery occlusive disease.