Effects of smoking on spontaneous and induced sister chromatid exchanges in lymphocytes |
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Authors: | T Nagaya H Toriumi |
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Affiliation: | 1. Department of Public Health, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-shi 500 Japan;2. Department of Hygiene, Daido Hospital, 9 Hakusui-chyo, Minami-ku, Nagoya-shi 457 Japan |
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Abstract: | Spontaneous and mitomycin C-induced sister chromatid exchanges (SCEs) in lymphocytes were analyzed in 24 non-smokers and 24 sex- and age-matched smokers. Mean spontaneous SCE frequency for non-smokers was 9.8 SCEs/cell, and that for smokers was 11.5 SCEs/cell. The difference was statistically significant (P less than 0.001 by t-test). These results suggest that spontaneous SCE frequency in lymphocytes is useful for evaluation of biological effects of environmental mutagens. However, we could not find any effects of smoking on the sensitivities of lymphocytes to mitomycin C in vitro. The effects of mutagens on humans may be independent of one another. |
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Keywords: | Environmental mutagens sensitivities to mutagens monitoring SCE sister chromatid exchange |
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