| 金银花中抗紫外线照射诱导的细胞凋亡作用的活性成分 |
| |
| 引用本文： | 王琦,黄健,孙博航,高慧媛,吴立军. 金银花中抗紫外线照射诱导的细胞凋亡作用的活性成分[J]. 中药研究与信息, 2008, 0(12): 23-25 |
| |
| 作者姓名： | 王琦 黄健 孙博航 高慧媛 吴立军 |
| |
| 作者单位： | 沈阳药科大学中药学院,辽宁沈阳110016 |
| |
| 摘 要： | 目的：研究金银花中抗紫外线照射诱导的细胞凋亡作用的活性成分。方法：以体外活性筛选为活性追踪体系，采用硅胶、Sephadex LH-20柱色谱法和重结晶等进行化学成分分离，通过化合物的理化性质和谱学数据确定化合物的结构。结果：从金银花活性部位中分离鉴定4个化合物，分别为5-O-咖啡酰基奎尼酸丁酯（1）、4-O-咖啡酰基奎尼酸（2）、绿原酸（3）和芦丁（4），其中化合物2和3具有较强的抗紫外线照射诱导细胞凋亡的作用。
|
| 关 键 词： | 金银花 细胞凋亡 活性成分 |
Bioactive Constituents with Inhibition Effects on the Cells Apoptosis Induced by Ultraviolet Irradiation from Honeysuckle Flower |
| |
| Wang Qi Huang Jian,Sun Bohang,Gao Huiyuan,Wu Lijun. Bioactive Constituents with Inhibition Effects on the Cells Apoptosis Induced by Ultraviolet Irradiation from Honeysuckle Flower[J]. Research & Information on Traditional Chinese Medicine, 2008, 0(12): 23-25 |
| |
| Authors: | Wang Qi Huang Jian Sun Bohang Gao Huiyuan Wu Lijun |
| |
| Affiliation: | (Shenyang Pharmaceutical University, School of Traditional Chinese Materia Medica, Shenyang Liaoning 110016, China) |
| |
| Abstract: | Objective： To isolate the bioactive constituents with inhibition effects on the cells apoptosis induced by ultraviolet irradiation from Honeysuckle Flower. Methods： The active compounds were isolated by bioassay-guided isolation with silica gel and Sephadex LH-20 columns chromatographic, and recrystallized methods. The structures of the compounds were identified by their physic-chemical properties and spectroscopic analysis. Results： Four compounds were obtained and identified as butyl 5-O-caffeoylquinic acid ester （ 1 ）, 4-O-affeoylquinic acid （2）, chlorogenic acid （3）, and rutin （4） . Compounds 2 and 3 showed the significant effects on the cells apoptosis induced by ultraviolet irradiation. |
| |
| Keywords: | Honeysuckle Flower Cells apoptosis Bioactive constituents |
| 本文献已被 维普 等数据库收录！ |
|
