血浆同型半胱氨酸含量与脑出血患者预后关系分析

目的探讨血浆同型半胱氨酸（Hcy）与脑出血预后的关系。方法脑出血患者148例作为观察组，另设健康体检者160例作为对照组，测定空腹血浆Hcy浓度。结果脑出血患者血浆Hcy水平（19．2±8．8）μmol／L，明显高于健康对照组的（12．5±4．4）μmol／L，差异有统计学意义（P〈0．05）。脑出血患者血浆Hcy浓度与预后关系：血浆Hcy浓度升高者，预后差，病死率高。血浆Hcy水平与患者神经功能障碍程度关系：脑出血患者神经功能缺损评分，中重型神经功能缺损者血浆Hcy水平与轻型神经功能缺损者比较，血浆Hcy水平高者神经功能缺损评分高，差异有统计学意义（P〈0．05）。结论高Hcy血症可能参与脑出血的发病，高Hcy血症是脑出血的重要危险因素。此外，血浆Hcy可作为判断脑出血患者病情轻重及预后的指标之一。

Study on the serum level of homocysteine and the prognosis of cerebral hemorrhage

Objective To investigate the serum homocysteine and cerebral hemorrhage prognosis. Methods 148 patients with cerebral hemorrhage as the observation group, a separate 160 cases of healthy volunteers as control group were measured fasting plasma homocysteine concentration. Results The plasma Hcy levels （ 19. 2 ± 8.8 ） was significantly higher than the control group （ 12. 5 ±4.4） , P 〈 0.05. Plasma Hey concentrations in patients with cerebral hemorrhage, indicating a poor prognosis and those who recovered compared to those of blood Hcy concentration, poor prognosis and high mortality. Patients with cerebral hemorrhage and severe neurological deficit scores had significant difference in plasma Hcy concentration, compared with those with low neurological deficit scores（ P 〈 0. 05 ）. Conclusions High Hey hyperlipidemia may be involved in the pathogenesis of cerebral hemorrhage, high Hcy hyperlipidemia are important risk factors for cerebral hemorrhage, in addition, Hcy could be used as indicators of severity and prognosis.