初治涂阳肺结核病人规范管理和全程督导短程化疗实施性研究

目的　探索适合我国广大农村，特别是老少边穷地区有效的病人管理方式。方法 在河北省20个县选取初治涂阳肺结核病人，以病人所在乡为单位随机分入两组，即规范管理组和全程督导组。两组病人均应用初治涂阳短程化疗方案 (2H₃R₃Z₃E₃(S₃)/4H₃R₃)进行治疗。观察两种管理方式下病人的疗效及中断治疗情况。结果 疗程结束时，规范管理组与全程督导组病人的痰菌阴转率分别为97.1%和98.5%，断药率分别为0.2%和0.12%，均无明显差异。结论 规范管理可获得与全程督导同样的效果。

An operational control research of two different case-management methods for new smear-positive pulmonary tuberculosis cases

Objective To seek an effective case management methods to be used in villages,especially in remote and poor areas of our country.Methods To select new smear positive pulmonary TB cases in 20 counties of Hebei province and to divide them into two groups,namely standardized self administrative treatment and directly observed treatment.All of selected patients were treated with initial smear positive short course regimen:2H 3R 3Z 3E 3(S 3)/4H 3R 3,and observed the outcomes and the situation of interrupted treatment under two different case management methods.Results By the end of treatment,the sputum conversion rate of the patients under standardized self administrative treatment and directly observed treatment was 97.1% and 98.5% respectively and the interrupted treatment rate was 0.2% and 0.12% respectively.Conclusion The same effectiveness can be gained between standardized self administrative treatment and directly observed treatment.