FT-IR study on solvent effects in building blocks of bioactive compounds. V |
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Authors: | C Conti R Galeazzi E Giorgini G Tosi |
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Affiliation: | aDipartimento di Scienze dei Materiali e della Terra, Università Politecnica delle Marche, via Brecce Bianche, 60131 Ancona, Italy |
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Abstract: | 3-Hydroxy-4-hydroxymethyl pyrrolidin-2-ones, easily prepared from the Baylis–Hillman adduct 1-ethyl-4-methyl-2-hydroxy-3-methylenebutanedioate, are useful intermediates in the synthesis of bioactive compounds. In order to understand the mechanism involved in this reaction, vibrational and Montecarlo molecular mechanics conformational analysis on 1-ethyl-4-methyl-2-hydroxy-3-methylenebutanedioate were carried out, confirming the existence of a low energy intramolecular H-bonded five-member ring. |
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Keywords: | Solvent effects Infrared spectroscopy Hydrogen bonding Conformational analysis |
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