| 环丙沙星哌嗪化缩合方法的研究 |
| |
| 引用本文： | 汪敦佳 陈永洲. 环丙沙星哌嗪化缩合方法的研究[J]. 化学反应工程与工艺, 1997, 13(3): 322-325 |
| |
| 作者姓名： | 汪敦佳 陈永洲 |
| |
| 作者单位： | 湖北师范学院化学系 |
| |
| 摘 要： | 采用无水哌嗪、活化喹啉环和活化哌嗪三种缩合方法制备了环丙沙星，并比较了它们各自的反应摩尔比、温度、时间及反应收率，优选得到了其最佳哌嗪化缩合方法为活化哌嗪法，该法收率高、产品质量好，易于工业化生产
|
| 关 键 词： | 环丙沙星 哌嗪化 缩合 制备 |
STUDY ON THE PIPERAZINE CONDENSATION FOR PREPARATION OF CIPROFLOXACIN |
| |
| Wang Dunjia Chen Yongzhou Wang Guohong. STUDY ON THE PIPERAZINE CONDENSATION FOR PREPARATION OF CIPROFLOXACIN[J]. Chemical Reaction Engineering and Technology, 1997, 13(3): 322-325 |
| |
| Authors: | Wang Dunjia Chen Yongzhou Wang Guohong |
| |
| Abstract: | The antibacterial ciprofloxacin was prepared by various piperazine condensation, such as anhydrous piperazine, activated quinoline and activated piperazine, and their reaction time, reaction temperature, proportion of raw materials and yield were compared. The results showed that activated piperazine condensation was a best method and the yield was increased from about 70% to over 84%. |
| |
| Keywords: | Ciprofloxacin Piperazine Condensation |
| 本文献已被 CNKI 维普 等数据库收录！ |
