IGF-1在卵巢浆液性肿瘤中的表达及意义

目的:探讨胰岛素生长因子(insulin-likegrowthfactor-1,IGF-1)在卵巢浆液性肿瘤中的表达及与卵巢浆液性腺癌生物学行为、预后的关系,以期为该肿瘤早期诊断、治疗及判断预后提供依据。方法:应用免疫组化ELIVISON二步法,检测IGF-1在37例卵巢浆液性腺癌、16例卵巢交界性浆液性肿瘤、12例良性卵巢浆液性肿瘤组织中的表达,并对37例卵巢浆液性腺癌患者进行随访。结果:①卵巢浆液性腺癌、交界性浆液性肿瘤、良性卵巢浆液性肿瘤组织中IGF-1的阳性表达率分别为64.86%(24/37)、43.75%(7/16)、8.33%(1/12),卵巢浆液性腺癌组织中IGF-1的表达高于卵巢交界性浆液性肿瘤和良性卵巢浆液性肿瘤,卵巢交界性浆液性肿瘤又高于良性卵巢浆液性肿瘤,差异均有统计学意义(P<0.05)。②卵巢浆液性腺癌组织中IGF-1蛋白表达与病理分级、淋巴结转移相关(P<0.01),而与临床分期无关(P>0.05)。③卵巢浆液性腺癌组织中IGF-1蛋白表达的阳性率在3年以上生存组中均显著低于3年内死亡组(P<0.01)。结论:①IGF-1蛋白在卵巢良性浆液性肿瘤、交界性浆液性肿瘤、卵巢浆液性腺癌组织中阳性表达率呈逐渐升高的趋势,其表达差异有统计学意义,提示IGF-1参与了肿瘤由良性向恶性转化、发展,有望成为卵巢癌早期的诊断辅助标记。②卵巢浆液性腺癌中IGF-1蛋白表达促进癌演进,并与癌细胞转移、患者预后密切相关。

Expression and significance of IGF-1 in ovarian serous tumor

Objective:To study the expression of HIF-1α in ovarian serous tumor and to investigate the relationship between the expression and biological behavior,prognosis of ovarian serous adenocarcinoma,to provide evidence for early diagnosis,treatment and prognosis of the tumor.Methods:The expression of IGF-1 in 37 cases of ovarian serous adenocarcinoma,16 cases of ovarian borderline serous tumor and 12 cases of benign ovarian serous tumor were detected by ELIVISON to follow-up the patients of ovarian serous adenocarcinoma mentioned above.Results:①The expressions of IGF-1 were observed in 8.33%,43.75% and 64.86% of benign ovarian serous tumors,ovarian borderline serous tumors and ovarian serous adenocarcinomas respectively.Expression rates of IGF-1 in ovarian borderline serous tumors and ovarian serous adenocarcinomas were significantly higher than those in benign ovarian serous tumors(P<0.05).②Statistical analysis revealed that the expression of IGF-1 was related to histological grade and lymphatic metastasis(P<0.01),whereas there was no relationship with clinical stage(P>0.05).③The positive rate of IGF-1 in survival group was much lower than that of the group of patients who died in 3 years(P<0.01).Conclusion:①The expression of IGF-1 has a tendency of increasing in benign ovarian serous tumor,ovarian borderline serous tumor and ovarian serous adenocarcinoma.IGF-1 participates in the procedure of benign tumor transformed to malignant,which is expected to be the diagnostic-aid marker in early diagnosis of ovarian carcinoma.②IGF-1 can promote the cancer progression,meaningwhile,it is strongly correlated with differentiation,metastasis and prognosis.