肺复康方治疗中晚期非小细胞肺癌32例

目的:观察中药肺复康方治疗中晚期非小细胞肺癌的疗效。方法:将64例患者随机分为两组各32例。对照组单纯采用GP或TP方案化疗,治疗组单纯采用中药肺复康方治疗。观察原发病灶疗效、生存率、生活质量变化,毒副反应发生率,免疫功能等。结果:两组原发病灶有效率比较,治疗组15.63%,对照组40.63%。差异有显著性意义(P<0.05),治疗组低于对照组,1年及2年生存率治疗组分别为68.75%,43.75%,对照组分别为43.75%,21.88%,两组生存率比较,差异均有显著性意义(P<0.05)。治疗后生活质量改善有效率治疗组为78.12%,对照组为45.62%,两组比较,差异有显著性意义(P<0.05)。两组毒副反应中恶心呕吐、白细胞下降及血小板下降的发生率比较,差异均有非常显著性差异(P<0.01),治疗组低于对照组。两组治疗后肝肾功能变化中谷丙转氨酶、尿素氮升高率比较,差异有非常显著性或显著性差异(P<0.01,P<0.05),提示对照组肝肾功能损害大于治疗组。两组治疗后免疫功能变化比较,在NK、IL-2、CD4+/CD8+等方面,差异均有非常显著性意义(P<0.01),治疗组优于对照组。结论:单纯中药肺复康方治疗中晚期非小细胞肺癌的疗效优于单纯化疗。

Clinical Observation on 40 Cases of Prescription with Feifu Kang in the Treatment of Advanced Non-Small Cell Lung Cancer

Objective:To observe the curative effect of Feifu Kang in the treatment of advanced non-small cell lung cancer.Methods:64 patients with advanced cancer were allocated to two groups randomly.The patients in control group were given GP or TP Chemotherapy.The patients in treatment group were given pure traditional Chinese medicine with Feifu Kang.The size of the primary lesion,survival rate,living quality,adverse reaction rate and immune function were observed.Results:Compairing the effect of the primary lesion,the treatment group was 15.63%,the control group was 40.63%,the different was significant(P<0.05).The effect of the treatment group was lower than control group.1-year and 2-year survival rate of the treatment group were 68.75% and 43.75%,the control group were 43.75% and 21.88%.Comparing survival rate,the different was significant(P<0.05).Comparing the efficiency of improved living quality after treatment,the treatment group was 78.12%,the control group was 45.62%,the different was significant(P<0.05).Comparing adverse reaction with the rate of nausea and vomiting,leukopenia and thrombocytopenia,the different was very significant(P<0.01),the treatment group was lower than control group.Comparing the increased rate of alanine aminotransferase and blood urea nitrogen with the change of liver and kidney function after treatment,the different was very significant or significant(P<0.01,P<0.05),which prompt liver and kidney dysfunction in the control group was greater than in that in the treatment group.Comparing immune function after treatment,in the aspects of NK,IL-2,CD+4/CD+8,the difference was very significant(P<0.01),the treatment group was better than the control group.Conclusion:The curative effect of pure traditional Chinese medicine with Feifu Kang was better than chemotherapy alone.