| 视神经切断术后视网膜内信号转导子与转录激活子STAT3蛋白的表达变化 |
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| 引用本文： | 刘猛,张艳,陈白羽,于恩华.视神经切断术后视网膜内信号转导子与转录激活子STAT3蛋白的表达变化[J].解剖学报,2004,35(4):354-357. |
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| 作者姓名： | 刘猛 张艳 陈白羽 于恩华 |
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| 作者单位： | 北京大学医学部基础医学院解剖学系,北京,100083 |
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| 基金项目： | 北京市自然科学基金 ( 70 2 2 0 18)资助项目，北京大学“985”青年科研启动基金资助项目 |
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| 摘 要： | 目的 探讨视神经损伤后，信号转导子与转录激活子(STAT3)蛋白在视网膜内表达和分布的变化。方法 免疫细胞化学、Westetn blot及计算机图像分析技术。结果 视神经切断术后，视网膜内STAT3表达水平上调，术后1d达到高峰，并出现核转位增多现象。5d后STAT3水平逐渐下降至正常。结论 Janus激酶一信号转导子与转录激活子(JAK-STAT)信号转导途径可能通过STAT3蛋白的活化，参与视神经切断后视网膜内的病理改变过程。
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| 关 键 词： | 信号转导子与转录激活子 视网膜 神经切断术 Janus激酶一信号转导子与转录激活子 金黄地鼠 |
CHANGES OF STAT3 EXPRESSION IN RETINA AFTER TRANSECTION OF OPTIC NERVE |
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| LIU Meng ,ZHANG Yan,CHEN Bai-yu,YU En-hua.CHANGES OF STAT3 EXPRESSION IN RETINA AFTER TRANSECTION OF OPTIC NERVE[J].Acta Anatomica Sinica,2004,35(4):354-357. |
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| Authors: | LIU Meng ZHANG Yan CHEN Bai-yu YU En-hua |
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| Affiliation: | LIU Meng *,ZHANG Yan,CHEN Bai-yu,YU En-hua |
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| Abstract: | Objective To study the expression and distribution of protein STAT3 in the retina after optic nerve transection. Methods Immunocytochemistry, Western blot and computer image analysis techniques were used. Results After optic nerve transection, STAT3 levels in the retina was highly up-regulated, the peak of which appeared at day 1 postaxotomy, then decreased gradually to the normal level 5 days later. More translocations of STAT3 to the nucleus were seen.Conclusion JAK-STAT signal transduction pathway was involved in the pathological processes in the retinal after transection of the optic nerve. |
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| Keywords: | STAT3 Retina Axotomy JAK-STAT Hamster |
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