呼出气一氧化氮联合降钙素原和C反应蛋白在哮喘诊治中的价值

对哮喘急性发作期60例患者治疗前测定呼出气一氧化氮（FeNO）、血降钙素原（PCT）、CRP水平，并进行痰细菌培养；根据痰培养结果将患者分为有细菌感染组（A组）、无细菌感染组（B组）。临床缓解期时重复上述指标检测。急性发作期时患者FeNO值显著高于临床缓解期（P〈0．05），A组FeNO与B组相比差异无统计学意义（P〉0．05）；急性发作期，A组血PCT、CRP显著高于B组（P均〈0．05）；A组临床缓解期血PCT、CRP显著低于急性发作期（P均〈0．05）；B组临床缓解期血PCT、CRP与急性发作期比较，差异无统计学意义（P〉0．05）。临床缓解期，A、B两组血PCT、CRP比较差异亦无统计学意义（P〉0．05）。

Values of fractional exhaled nitric oxide plus serum procalcitonin and C-reactive protein in the evaluation of asthma

A total of 60 patients with an acute attack of asthma were studied. On presentation, fractional exhaled nitric oxide （FeNO） and the serum concentrations of procalcitonin （PCT） and C-reactive protein （CRP） were measured. And sputum culture was also performed. The patients were re-evaluated while returning to their clinical remission states. They were classified into 2 groups： patients with bacterial infection （group A） and those with nonbacterial infection （group B）. The levels of FeNO were significantly higher in patients with acute exacerbation than those in remission. No difference existed between groups A and B （ P 〉 0. 05 ）. The levels of PCT and CRP of group A with acute exacerbation were significantly higher than those of group B（ all P 〈 0. 05 ）. While in remission, the levels of PCT and CRP decreased significantly in group A （P 〈0. 05） ; But compared with exacerbation, the levels of PCT and CRP showed no change in group B （ P 〉 0. 05 ）. And no differences existed between two groups while in remission （ P 〉 0. 05 ）. An elevation of FeNO indicates the acute exacerbation of asthma. And the increased serum levels of PCT and CRP are associated with bacterial infection.