| 正交试验优选黄连中小檗碱提取工艺的研究 |
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| 引用本文： | 刘圣,唐丽琴,陈礼明,李矗,张善堂,王钦茂,陈光亮,陈敬,汪友明.正交试验优选黄连中小檗碱提取工艺的研究[J].中国药房,2004,15(1):18-20. |
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| 作者姓名： | 刘圣 唐丽琴 陈礼明 李矗 张善堂 王钦茂 陈光亮 陈敬 汪友明 |
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| 作者单位： | 1. 安徽省立医院药剂科,合肥市,230001
2. 安徽中医学院,合肥市,230038 |
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| 摘 要： | 目的 :筛选黄连中小檗碱的提取工艺。方法 :采用正交试验设计系统考察乙醇浓度、乙醇用量、硫酸加入量、提取时间、提取次数5因素对盐酸小檗碱得率的影响。结果 :黄连中小檗碱适宜的提取工艺 :溶剂为6倍量80 %乙醇 ,乙醇中硫酸加入量为0 25 % ,提取时间为每次1 5h ,提取次数为3次。结论 :以该工艺制备的盐酸小檗碱精制品含量在90 %以上 ,适合工业化生产。
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| 关 键 词： | 黄连 小檗碱 正交试验 提取工艺 |
| 文章编号： | 1001-0408(2004)01-0018-03 |
| 修稿时间： | 2003年1月27日 |
Study on Extraction Technology of Berberine from Rhizoma Coptidis by the Method of Orthogonal- test Optimization |
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| LIU Sheng,TANG Liqin,CHEN Liming,LI Chu,ZHANG Shantang.Study on Extraction Technology of Berberine from Rhizoma Coptidis by the Method of Orthogonal- test Optimization[J].China Pharmacy,2004,15(1):18-20. |
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| Authors: | LIU Sheng TANG Liqin CHEN Liming LI Chu ZHANG Shantang |
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| Abstract: | OBJECTIVE:To optimize the extraction technology of berberine from Rhizoma Coptidis.METHODS:The orˉthogonal-test method was adopted to research the effects of5factors,including the concentration and volume of alcohol,the concentration of H 2 SO 4 ,the duration and times of extraction on the yielding rate of berberine from Rhizoma Coptidis.RESUL TS:The optimum technology of extracting berberine from Rhizoma Coptidis was described as follows:The concentration of alˉcohol containing0.25%H 2 SO 4 was80%,and volume of alcohol was6times raw herb.To extract the herb for3times was optimum and duration of extraction was1.5h for each time.CONCLUSION:The content of berberine in the product is over90%,so this technology is suitable for industrialized production. |
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| Keywords: | Rhizoma Coptidis berberine orthogonal-test extraction technology |
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