| 慢性丙型肝炎干扰素治疗疗效影响因素分析 |
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| 引用本文： | 张琳,付海超,曲思麦,刘江福,窦晓光.慢性丙型肝炎干扰素治疗疗效影响因素分析[J].现代预防医学,2011,38(12):2394-2396. |
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| 作者姓名： | 张琳 付海超 曲思麦 刘江福 窦晓光 |
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| 作者单位： | 中国医科大学附属盛京医院感染科,沈阳,110004 |
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| 基金项目： | 辽宁省高等学校科研项目计划基金资助项目(2008852); 十一五国家科技重大专项基金资助项目(2008zx10002-013) |
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| 摘 要： | 目的]分析病毒和宿主因素及治疗过程中不同病毒学应答模式对慢性丙型肝炎干扰素(IFN)治疗结局的影响,为临床干扰素抗病毒治疗疗效预测及治疗方案选择提供依据。方法]分析30例应用干扰素治疗的慢性丙型肝炎患者基因型、病毒载量、IFN种类、治疗过程中不同的病毒学应答模式以及年龄、性别、体重、肝脏脂肪变性等多种因素与干扰素疗效的关系。HCV基因分型应用直接测序法,HCVRNA载量采用荧光定量PCR法。结果]持续应答(SVR)组和无应答(NR)组和患者的年龄、性别、体重无差异;NR组脂肪肝患者明显多于SVR组(χ2=5.662,P﹤0.05);HCVRNA载量两组无差异(SVR组6.32±0.828vsNR组6.08±0.892);基因型1b型患者的SVR率(35.7)低于2a型(67.7),Peg-干扰素治疗SVR率(67.7)高于普通干扰素(41.7)。SVR组RVR获得率达71.4,明显高于NR组(12.5);EVR的获得率两组均较低(28.6vs25),且差异无统计学意义。结论]病毒和宿主因素中,年龄、性别、体重与干扰素疗效无关,肝脏脂肪变性、基因型1b型患者干扰素治疗SVR率较低。长效干扰素疗效高于普通干扰素。RVR的出现对SVR的获得有预测作用。
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| 关 键 词： | 慢性丙型肝炎 干扰素 病毒 宿主 |
ANALYSIS OF THE INFLUENCING FACTORS OF THE INTERFERON THERAPY IN TREATMENT OF PATIENTS WITH CHRONIC HEPATITIS C |
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| ZHANG Lin,FU Hai-chao,QU Si-mai,et al..ANALYSIS OF THE INFLUENCING FACTORS OF THE INTERFERON THERAPY IN TREATMENT OF PATIENTS WITH CHRONIC HEPATITIS C[J].Modern Preventive Medicine,2011,38(12):2394-2396. |
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| Authors: | ZHANG Lin FU Hai-chao QU Si-mai |
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| Affiliation: | ZHANG Lin,FU Hai-chao,QU Si-mai,et al.(Department of Infectious Disease,Shengjing Hospital,China Medical University,Shenyang 110004,China) |
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| Abstract: | Objective]To provide a good treatment plan and predict the outcome of interferon for patients with chronic hepatitis C.Methods]Factors which come from virus,host and response mode to IFN treatment were analyzed.The indexes included HCV genotype,HCVRNA load,IFN type,different response mode to treatment,age,gender,weight and hepatic adipose infiltration etc.,The relationship between these factors and the effectiveness of IFN treatment was analyzed.The differentiation of HCV genotype used the method of direc... |
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| Keywords: | Chronic hepatitis C Interferon Virus Host |
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