| 普拉洛芬滴眼液中防腐剂苯扎氯铵的含量测定 |
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| 引用本文： | 臧红波,于海岩,宋成君.普拉洛芬滴眼液中防腐剂苯扎氯铵的含量测定[J].黑龙江医药,2011,24(4):526-528. |
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| 作者姓名： | 臧红波 于海岩 宋成君 |
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| 作者单位： | 1. 哈高科白天鹅药业集团有限公司
2. 哈尔滨瑞程阳光医药科技有限公司 |
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| 摘 要： | 目的:建立普拉洛芬滴眼液中防腐剂苯扎氯铵的含量测定方法.方法:采用Diamonsfl C18色谱柱,规格为4.6×250mm,粒度为5μm,以0.02mol/L庚烷磺酸钠溶液(含0.1%三乙胺,用磷酸调节pH值3.45±0.1)-乙腈(35:65)为流动相;流速为1.5ml/min;检测波长208nm;柱温:40℃.结...
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| 关 键 词： | 高效液相色谱法 普拉洛芬滴眼液 幕扎氯铵 |
Determination of Preservative Benzalkonium Chloride Content in Pranoprofen Eys Drops by HPLC |
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| Affiliation: | Zang Hongbo,et al Harbin High-Technology Baitianer Pharmaceutical Group Co.,Ltd |
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| Abstract: | Objective：A HPLC method for determination of preservatives Benzalkonium Chloride in Pranoprofen Eye Drops was established.Methods：A C18 column（4.6×250mm,5μm） was used with the mobile phase of 0.02mol/L Heptane sulfonate solution（0.1% Triethylamine adjusted pH to 3.45±0.1 with phosphoric acid） -acetonitrile（35∶65） ,at the detectionwavelength of 208nm,at the flow of 1.5ml/min and the column temperture of 40℃.Results：The content of C12 in the Benzalkonium chloride was the highest,and the contents of C14 and C16 in the Benzalkonium chloride didn＇t reach the limit of detection.The peaks of C12,Pranoprofen and blank materials can achieve an effective separation.Conclusion：The HPLC method showed a sensitive,accurate,reproducible and can be effective in the determination content of preservatives benzalkonium chloride in Pranoprofen eye drops. |
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| Keywords: | HPLC Pranoprofen Eye Drops benzalkonium chloride |
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