激光诱导间质肿瘤热疗的数值模拟和实验研究

本文在考虑生物组织物性动态变化的情况下建立了激光诱导间质肿瘤热疗(LITT)的物理数学模型,采用MonteCarlo方法数值模拟了LITT中激光能量在生物组织内的传输过程,基于Pennes生物传热方程和Arrhenius方程数值求解了组织内的温度分布和热损伤体积的变化,分析了热物性及血液灌注率的动态变化对LITT过程的影响,并与相应的离体实验结果进行了对比。数值模拟结果表明,组织的热物性及血液灌注率的动态变化对于热损伤体积的变化具有重要的影响。因此在激光诱导间质肿瘤热疗的数值模拟中应该考虑热物性及血液灌注率的动态变化以期为临床治疗方案的制定提供更为准确的依据。

NUMERICAL SIMULATION AND EXPERIMENTAL STUDIES OF LASER-INDUCED INTERSTITIAL THERMOTHERAPY

A physical and mathematical model considering the dynamic changes of tissue physical properties was developed in this paper to simulate the energy and temperature history during laser-induced interstitial thermotherapy (LITT). The energy transport of laser in tissue was simulated using the Monte Carlo method, and then the temperature distribution and the thermal damage volume were numerically calculated based on the Pennnes' Bioheat Equation and Arrhenius assumptions. The effects of the dynamic changes of thermal properties of tissue as well as those of the blood perfusion were analyzed numerically. Simulation results were also compared with corresponding ex vivo experimental results. The numerical results showed that the dynamic changes of tissue physical properties significantly affected the thermal damage volume and should be carefully considered to properly predict the clinical procedure.