粤东地区10日序贯疗法治疗幽门螺杆菌感染的临床观察

目的评价在粤东地区采用10d序贯疗法与传统三联疗法治疗幽门螺杆菌(Hp)感染的临床疗效。方法将汕头市、揭阳市、汕尾市经胃镜下胃黏膜Hp快速尿素酶试验阳性或者14C-尿素呼气试验阳性的患者132例,随机分为2组,治疗组67例,采用10d序贯疗法治疗,即前5d口服泮托拉唑20mg+阿莫西林1000mg,bid,后5d泮托拉唑20mg+克拉霉素500mg+甲硝唑400mg,bid。对照组65例,采用标准三联疗法:泮托拉唑20mg+甲硝唑400mg+阿莫西林1000mg,bid,疗程7d。疗程结束后4周行快速尿素酶试验或者14C-尿素呼气试验检测Hp。结果治疗组Hp根除率为94.03%,对照组73.85%,两组比较有显著性差异(P0.05)。结论在粤东地区采用10d序贯疗法对幽门螺杆菌感染的根除率高于传统的7d三联疗法。

A clinic study of 10-day sequential therapy for Helicobacter pylori infection in Guangdong Eastern

Objective To compare the effect of 10-day sequential therapy and traditional triple therapy for eradication ofHelicobacterpylori （H.pylori）in Guangdong Eastern. Methods One hundred and thirty-two patients with H.pylori infection detected by rapid urease test during gastroscopy or ^14C-urea breath test were randomly divided into two groups. Sixty-seven patients received a 10-day sequential therapy, treated with pantoprazole（20 mg, bid） plus anaoxillin（1,000 nag, bid） at first five days, followed by pantoprazole（20 mg）, clarithromycin（500 nag） and metronidazole （400 nag） twice daily at the second five days. The control group （65 patients） received a triple therapy, treated with pantoprazole（20 mg）, amoxillin（1,000 mg） and metronidazole （400 mg） twice daily for seven days. Rapid urease test or ^14C-urea breath test was reexamined 4 weeks after treatment. Results The eradication rate was 94.03% in 10- day sequential therapy group and 73.85% in control group. The difference between two groups was statistically significant （P 〈 0.05）. Conclusion 10-day sequential therapy is more effective than traditional triple therapy in Guangdong Eastern.