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The role of HPV RNA transcription,immune response‐related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer
Authors:Knut Krohn  Markus Kreuz  Andreas Boehm  Anett Reiche  Ulrike Scharrer  Dirk Halama  Julia Bertolini  Ulrike Bauer  Dana Holzinger  Michael Pawlita  Jochen Hess  Christoph Engel  Dirk Hasenclever  Markus Scholz  Peter Ahnert  Holger Kirsten  Alexander Hemprich  Christian Wittekind  Olf Herbarth  Friedemann Horn  for the Leipzig Head  Neck Group
Affiliation:1. Faculty of Medicine, Interdisciplinary Center for Clinical Research, University of Leipzig, Leipzig, Germany;2. Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany;3. Clinic for Otorhinolaryngology, University Hospital Leipzig, Leipzig, Germany;4. LIFE—Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany;5. Clinic for Maxillofacial Surgery, University Hospital Leipzig, Leipzig, Germany;6. Institute of Pathology, University Hospital Leipzig, Leipzig, Germany;7. Division of Genome Modifications and Carcinogenesis (F020), Infection and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany;8. Research Group Molecular Mechanisms of Head and Neck Tumors, German Cancer Research Center (DKFZ), Heidelberg, Germany;9. Section Experimental and Translational Head and Neck Oncology, Department of Otolaryngology, Head and Neck Surgery University Heidelberg, Heidelberg, Germany;10. Faculty of Medicine, Institute of Environmental Medicine and Hygiene, University of Leipzig, Leipzig, Germany;11. Institute of Clinical Immunology and Transfusion Medicine, University Hospital, Leipzig, Germany
Abstract:
Keywords:head and neck squamous cell carcinoma  human papillomavirus  neck metastasis  gene expression  TP53  APC  consensus clustering
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