人巨细胞病毒与冠心病的临床相关性研究

目的探讨人巨细胞病毒（HCMV）感染与冠心病（CAD）的临床相关性。方法根据ELISA和PCR法检测120例冠心病患者血清HCMV-IgM及DNA,将患者分为HCMV阳性组和阴性组,分别检测两组血清TC、TG、LDL-C、HDL-C及hsCRP,比较其差异并分析与HCMV感染的相关性。结果 71例（59.2%）CAD患者为阳性组,其中AMI 8例（72.7%）,心绞痛22例（61.1%）,隐匿型CAD 41例（56.2%）;49例（40.8%）为阴性组。阳性组患者TC、TG、LDL-C及hsCRP均高于阴性组,两组间有显著性差异（P〈0.05）,而HDL-C两组无显著性差异;HCMV-IgM抗体滴度与LDL-C、hsCRP均呈正相关（r=0.376、0.332,均P〈0.05）。结论 HCMV感染严重程度与CAD病情密切相关,并且支持HCMV感染是CAD发病的独立危险因子之一。

Clinic correlation between human cytomegalovirus and coronary artery dDisease

Objective： To investigate the clinic correlation between human cytomegalovirus（HCMV） recent infection and coronaryartery disease（CAD）.Methods： By use of enzyme-linked immunosorbent assay（ELISA） and polymerase chain reaction（PCR） and on the basis of the results of HCMV-IgM and DNA detected in serum samples,120 cases of coronaryartery disease（CAD） were divided into HCMV positive group and negative group.The differences in the total cholesterol（TC）,triacylglycerol（TG）,low density lipoprotein-cholesterol（LDL-C）,high density lipoprotein-cholesterol（HDL-C） and high-sensitivity C-reactive protein（hsCRP） levels in the two groups were analyzed.Results： Seventy-one patients（59.2%） belonged to the positive group and 49 patients（40.8%） were in the negative group.The positive group consisted of 8 patients of acute myocardial infarction,22 patients of angina pectoris and 41 patients of latent coronary heart disease;The levels of TC,TG,LDL-C and hsCRP in the positive group were significantly higher than those in the negative group（P〈0.05）;There were positive correlations between level of HCMV-IgM and LDL-C,hsCRP respectively（r=0.376,0.332,P〈0.05）.Conclusion： There is correlation between degree of HCMV infection and CAD,and the theory that HCMV infection is one of the independent risk factors is certified.