Immunohistochemical localization of porcine diazepam-binding inhibitor (DBI) to rat endocrine pancreas |
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| Authors: | Olle Johansson Marita Hilliges Claes-Göran Östenson Elvi Sandberg Suad Efendic Viktor Mutt |
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| Affiliation: | (1) Department of Histology and Neurobiology, Karolinska Institutet, S-10401 Stockholm, Sweden;(2) Department of Biochemistry II, Karolinska Institutet, S-10401 Stockholm, Sweden;(3) Department of Endocrinology, Karolinska Sjukhuset, Stockholm, Sweden |
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| Abstract: | Summary The occurrence of diazepam-binding inhibitor (DBI), isolated and characterized from porcine upper intestine, was examined in the pancreas of Sprague-Dawley albino rats using indirect immunofluorescence. The polypeptide was found in the endocrine Langerhans islets and, utilizing double-labelling controls, it was shown to be present within the peripherally located glucagon-containing cells. Regulation of islet hormone production may therefore be under DBI control. |
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| Keywords: | Diazepam-binding inhibitor (DBI) DBI-like immunoreactivity Pancreas endocrine Immunohistochemistry Peptides Rat (Sprague-Dawley) |
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