| HPLC法测定氯雷他定片含量 |
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| 引用本文： | 康军,张鹤.HPLC法测定氯雷他定片含量[J].中国医药导报,2011,8(4):56-58. |
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| 作者姓名： | 康军 张鹤 |
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| 作者单位： | 辽阳市食品药品检验所,辽宁辽阳,111000 |
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| 摘 要： | 目的：建立测定氯雷他定片中氯雷他定含量的高效液相色谱法。方法：采用色谱柱为Diamonsil C18（200 mm×4.6 mm,5μm）;流动相为乙腈-磷酸盐缓冲液（用磷酸调节pH值至3.0）（70∶30）,流速为1.0 ml/min,检测波长为247 nm,柱温为25℃。结果：回归方程为Y=760 965X-82 937,r=0.999 2（n=6）。表明进样量在0.80～4.80μg范围内有良好的线性关系,平均回收率为99.60%,RSD为0.39%（n=9）。结论：本法测定氯雷他定片的含量简单、灵敏、重现性好,能够准确地控制药品质量。
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| 关 键 词： | 高效液相色谱法 氯雷他定片 含量测定 |
Content determination of Loratadine Tablets by HPLC |
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| KANG Jun,ZHANG He.Content determination of Loratadine Tablets by HPLC[J].China Medical Herald,2011,8(4):56-58. |
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| Authors: | KANG Jun ZHANG He |
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| Affiliation: | KANG Jun,ZHANG He(Liaoyang Institute for Food and Drug Control,Liaoning Province,Liaoyang 111000) |
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| Abstract: | Objective： To establish the content determination of Loratadine Tablets by HPLC method.Methods： The column was Diamonsil C18（200 mm × 4.6 mm,5 μm）;mobile phase was acetonitrile-phosphate buffer（pH value adjusted to 3.0 with phosphoric acid）（70∶30）;flow rate was 1.0 ml/min;detection wavelength was 247 nm;column temperature was 25℃.Results： The regression equation was Y=760 965X-82 937,r=0.999 2（n=6）,which showed that the sample had good linear relationship in the range of 0.80-4.80 μg;the average recovery was 99.60% with RSD of 0.39%（n=9）.Conclusion： This method is simple,sensitive and reproducible for the content determination of Loratadine Tablets.It can accurately control the drug quality. |
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| Keywords: | High performance liquid chromatography Loratadine Tablets Content determination |
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