| Cycin D_1在鼻腔鼻窦肿瘤中的表达 |
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| 引用本文： | 韩敏,陈瑛.Cycin D_1在鼻腔鼻窦肿瘤中的表达[J].山东医大基础医学院学报,2007(3). |
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| 作者姓名： | 韩敏 陈瑛 |
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| 作者单位： | 青岛大学医学院附属医院耳鼻咽喉-头颈外科 山东青岛266003(韩敏)，山东大学齐鲁医院耳鼻咽喉-头颈外科 山东济南250012(陈瑛) |
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| 摘 要： | 目的:探讨cycin D1在鼻腔鼻窦肿瘤中的表达及其临床意义。方法:采用免疫组化SABC法检测20例鼻腔鼻窦恶性肿瘤和10例相应部位良性病变的石蜡标本中cycin D1的表达。结果:鼻腔鼻窦肿瘤中cycin D1表达均为阳性,良性病变中为阴性或弱阳性。鼻腔鼻窦恶性肿瘤中cycin D1积分与患者年龄、性别、病变部位及病理类型无关(P>0.05)。Cycin D1积分与TNM分期、病理分级相关(P<0.05),且积分随肿瘤临床分期、分级逐渐升高。初诊病例与复发病例之间cyclin D1积分差异有统计学意义(P<0.05)。结论:Cycin D1在鼻腔鼻窦肿瘤的发生、发展及复发转移等临床病理过程中起重要作用。
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| 关 键 词： | CyclinD1 鼻窦肿瘤 免疫组织化学 |
Expression of cyclin D_1 in nasal sinus neoplasm |
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| HAN Min,CHEN Ying.Expression of cyclin D_1 in nasal sinus neoplasm[J].Journal of Preclinical Medicine College of Shandong Medical University,2007(3). |
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| Authors: | HAN Min CHEN Ying |
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| Affiliation: | HAN Min1,CHEN Ying2 |
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| Abstract: | Objective: To investigate the expression of cyclin D1 in nasal sinus neoplasm and its clinical significance.Method: SABC immunohistochemical technique was used to determine the expression of cyclin D1 in 20 samples of nasal sinus carcinoma and 10 samples of benign lesion.Results: Cyclin D1 was over-expressed in all nasal sinus carcinoma,whereas no or weak expression was determined in benign lesions.The cyclin D1 integral was not correlated with age,gender,site of tumor or pathologic type(P>0.05) but correlated with the TNM stage and histological grade(P<0.05).Moreover,it gradually increased following the increase of stage and histological grade.There were significances between cyclin D1 integral of preliminary cases and recurrence cases(P<0.05).Conclusion: Cyclin D1 may play an important role in tumor genesis. |
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| Keywords: | Cyclin D1 Nasal sinus neoplasm Immunohistochemisty |
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