内质网应激及线粒体功能障碍在糖尿病血管内皮损伤中作用的研究进展

血管内皮损伤是糖尿病血管并发症的起始环节,涉及多种机制,氧化应激被认为其中关键的环节,但补充外源性抗氧化剂的治疗目前仍存在争议。内质网及线粒体是参与细胞内活性氧生成的关键细胞器,探讨内质网应激、线粒体功能障碍及氧化应激之间的相互关系可能对于阐明糖尿病相关血管内皮功能障碍的发病机制有重要的意义。本文综述了近年关于内质网及线粒体功能障碍在糖尿病相关血管并发症中的研究进展并分析了二者的相互作用在氧化应激中的重要作用。

Research Progress of the roles of Endoplasmic ReticulumStress andMitochondria Dysfunction in Diabetic Related EndotheliumInjury

Endothelial injuried is the first step of the Diabetes Mellitus (DM) related vascular complication. It involved complexmechanisms and oxidative stress plays key role in endothelial dysfunction. But supplied of exogenous antioxidative drugs focus onoxidative stress still disputed. Endoplasmic reticulum and mitochondria play important role in ROS generation, hence, it is important toexplore the relationship of Endoplasmic reticulumstress(ERS), mitochondrial dysfunction and oxidative stress in DMrelated endotheliumdysfunction. In this review, we summarized the researches of endoplasmic reticulum and mitochondria dysfunction in the DM relatedvascular complication and also analyzed the relationship between ERS and mitochondria dysfunction in the oxidative stress.