| 地冰凝胶的制备与质量控制 |
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| 引用本文： | 洪清,袁曦,陈庆伟,朱善岚. 地冰凝胶的制备与质量控制[J]. 中国药房, 2005, 16(1): 32-33 |
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| 作者姓名： | 洪清 袁曦 陈庆伟 朱善岚 |
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| 作者单位： | 1. 福建医科大学附属第一医院药剂科,福州市,350005
2. 福州市药品检验所,福州市,350001 |
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| 摘 要： | 目的 :制备地冰凝胶 ,并建立其质量控制方法。方法 :以0 5%卡波姆940作为凝胶基质 ,采用高效液相色谱法测定制剂中醋酸地塞米松的含量 ,并进行稳定性考察和皮肤刺激性试验。结果 :醋酸地塞米松检测浓度在20～120μg/ml范围内线性关系良好 ,平均回收率为101 1% ,RSD=0 92% ;制剂稳定性良好 ,对皮肤无刺激作用。结论 :该制剂处方合理 ,制备工艺简便 ,质量控制方法简单、准确。
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| 关 键 词： | 凝胶 醋酸地塞米松 冰片 高效液相色谱法 |
| 文章编号： | 1001-0408(2005)01-0032-02 |
| 修稿时间： | 2004-03-31 |
Preparation and Quality Control of Dibing Gel |
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| HONG Qing,YUAN Xi,ZHU Shanlan. Preparation and Quality Control of Dibing Gel[J]. China Pharmacy, 2005, 16(1): 32-33 |
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| Authors: | HONG Qing YUAN Xi ZHU Shanlan |
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| Abstract: | OBJECTIVE:To prepare Dibing gel and establish its quality control method.METHODS:The0.5%Carbopol940was taken as the base of gel.The content of dexamethasone acetate was determined by HPLC.The stability and the skin irritation test were studied,too.RESULTS:The calibration curve of dexamethasone acetate was linear in the range of20～120μg/ml.The average recovery of dexamethasone acetate was101.1%,RSD=0.92%.The preparation was stable and had no irritation to skin.CONCLUSION:The gel was resonable in formulation,convenient in preparation technique,and simple and accurate in method of quality control. |
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| Keywords: | Gel Dexamethasone acetate Borneol HPLC |
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