Suture-Button固定与螺钉固定治疗下胫腓联合损伤的Meta分析

文题释义：Suture-Button固定：为缝合纽扣钢丝线缆系统固定,该固定方式强度不仅跟螺钉一样,治疗下胫腓联合损伤允许一定程度下胫腓联合生理微动,无须二次手术取出,不存在植入物疲劳。螺钉固定：是治疗下胫腓联合损伤的金标准,并且螺钉固定治疗下胫腓联合损伤已取得良好的临床效果,但仍有许多方面需进一步研究确定,如螺钉内固定的取出、螺钉置入等。背景：在胫腓联合损伤的临床治疗中,Suture-Button固定技术可取得与螺钉相似甚至比螺钉更好的疗效,但其并不能完全恢复损伤前的解剖复位和活动度,所以下胫腓联合损伤的最佳治疗方案仍存在争议。目的：系统评价Suture-Button固定与螺钉固定治疗下胫腓联合损伤的疗效。方法：通过检索EMBASE、Cochrane 数据库、PubMed数据库、万方数据库、CNKI中国期刊全文数据库,收集2005年1月至 2019年1月公开发表的有关Suture-Button固定与螺钉固定治疗下胫腓联合损伤的随机或非随机对照研究,严格评价纳入研究的文献质量,提取相关资料,利用RevMan 5.3软件对所有结局指标进行Meta分析。结果与结论：①最终纳入了12篇研究,其中4篇随机对照研究,8篇队列研究,总共564例患者,其中试验组进行Suture-Button固定,对照组进行螺钉固定;②Meta 分析显示：试验组完全负重时间短于对照组[WMD=-1.50,95%CI(-2.08,-0.92),P < 0.05],术后3,6,12,24个月的AOFAS评分优于对照组[WMD=6.50,95%CI(3.41,9.58),P < 0.05;WMD=2.87,95%CI(0.75,4.98),P < 0.05;WMD=2.67,95%CI(0.09,5.24),P < 0.05;WMD=5.79,95%CI(1.41,10.18),P < 0.05],两组手术时间、末次随访下胫腓重叠距离、末次随访下胫腓间隙及术后总并发症发生率比较差异均无显著性意义(P > 0.05);③结果表明与螺钉固定相比,Suture-Button固定治疗下胫腓联合损伤术后踝关节功能恢复更好、完全负重时间更早,且不用考虑螺钉断裂在手术的风险,其是除了螺钉技术之外治疗下胫腓联合损伤的另一种有效方式。ORCID: 0000-0003-2787-0498(田晨阳) 中国组织工程研究杂志出版内容重点：人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程

Suture-Button fixation and screw fixation for the treatment of distal tibiofibular syndesmosis injury: a meta-analysis

BACKGROUND: In the clinical treatment of distal tibiofibular syndesmosis injury, Suture-Button fixation technique can achieve similar results to, even better results than, those of screws, but it cannot fully recover the anatomical reduction and activity to those before injury. However, the optimal treatment of distal tibiofibular syndesmosis injury is still controversial. OBJECTIVE: To systematically evaluate Suture-Button fixation and screw fixation for the treatment of distal tibiofibular syndesmosis injury. METHODS: EMBASE, Cochrane database, PubMed database, Wanfang database, and CNKI were searched to retrieve randomized or non-randomized controlled trials regarding Suture-Button fixation and screw fixation for the treatment of distal tibiofibular syndesmosis injury published from January 2005 to January 2019. The quality of the included studies was strictly evaluated. Relevant data were extracted. A meta-analysis of all outcome measures was performed using RevMan 5.3 software. RESULTS AND CONCLUSION:(1) Twelve studies were included, including 4 randomized controlled trials and 8 cohort studies, involving 564 patients.(2) Meta-analysis results showed that Suture-Button fixation had shorter full weight-bearing time [WMD=-1.50, 95%CI(-2.08,-0.92), P < 0.05] than screw fixation method. Suture-Button fixation resulted in better AOFAS scores than screw fixation at 3, 6, 12, and 24 months after surgery [WMD=6.50,95%CI(3.41, 9.58), P < 0.05;WMD=2.87, 95%CI(0.75, 4.98), P < 0.05;WMD=2.67, 95%CI(0.09, 5.24), P < 0.05;WMD=5.79, 95%CI(1.41, 10.18), P < 0.05]. There were no significant differences in operation time, tibiofibular overlap at the last follow-up, tibiofibular clear space at the last follow-up, and the incidence of total postoperative complications after surgery between two fixation methods(P > 0.05).(3) These findings suggest that compared with screw fixation, Suture-Button fixation for the treatment of distal tibiofibular syndesmosis injury leads to better recovery of ankle joint function and an earlier time point for full weight bearing and does not need to consider the risk of screw fracture during the surgery. In addition to screw fixation, Suture-Button fixation is an effective way to treat distal tibiofibular syndesmosis injury.