水蛭素治疗不稳定心绞痛疗效观察

目的:评价水蛭素治疗不稳定心绞痛(UAP)的临床疗效。方法:将64例UAP患者随机分为治疗组、对照组各32例,均服用抗心肌缺血的基础药物,治疗组加服脉血康500mg,每天3次,连用4周。对照组口服阿司匹林100mg,每天1次。结果:治疗组总有效率90.62%,对照组总有效率71.88%(P<0.05),治疗组全血黏度、血浆黏度、血小板聚集率均显著降低(P<0.01),明显低于对照组(P<0.05)。结论:在常规治疗基础上联合水蛭素治疗不稳定心绞痛效果显著,副作用低,可减少心肌梗死的发生。

Curative Effect Observation on Unstable Angina Pectoris Treated by Hirudin

Objective：To study the clinical efficacy and safety of Hirudin in treatment of unstable angina pectoris. Methods：64 cases of unstable angina pectoris were randomly allocated into the Controlling group （receive aspirin daily 100mg） and Treating group（receive Hirudin 500mg ,tid, for 4 week）.Basic antimyocardial ischemia drugs were taken by both groups at the same time,Result：The efficient rate in Treating group was up to 90.62%,but Control group 71.88%,they were different remarkably （P 〈0.05）.Total blood viscosity,plasma viscosity and platelet aggregation rate in Treating group were significantly decreased （P 〈0.01）.Treating group was superior to Control group （P 〈0.05）.Conclusion：Hirudin combined with normal treatment is an effective and safe agent for treatment of unstable angina pectoris ,which decrese incidence of ayoearid infraction.