32例幼年黄色肉芽肿临床与病理分析

 目的:归纳总结幼年黄色肉芽肿的临床及组织病理特点。方法:回顾性分析2011年12月-2019年12月我院确诊的32例幼年黄色肉芽肿患儿的临床资料和组织病理学检查结果。结果:32例患儿皮损多表现为头面部、躯干、四肢黄色或黄褐色丘疹、结节,也可表现为红色或暗红色，有1例伴皮肤外症状。皮损组织病理特点可分为3种类型：早期（占12.50%），可见大量组织细胞浸润，散在多核巨细胞、淋巴细胞、少量嗜酸性细胞浸润；成熟期（占78.12%），可见典型泡沫细胞、多核巨细胞及Touton巨细胞；消退期（占9.38%），可见梭形细胞，少许组织细胞及多核巨细胞。免疫组化结果为CD68（+）、CD1a（-）、Langerin（-）及S-100（-）。结论:临床上根据典型皮损特点及病理表现一般可诊断幼年黄色肉芽肿，但临床上有必要行病理检查以帮助减少误诊率。

An analysis of clinical and pathological features of 32 cases of juvenile xanthogranuloma

Objective：To summarize the clinical and histopathological features of juvenile xanthogranuloma (JXG). Methods:The clinical manifestations and histopathological findings of 32 children with juvenile xanthogranuloma diagnosed and treated in our hospital from December 2011 to December 2019 were retrospectively analyzed. Results:The lesions were yellow or tawny, also red or dark red, papules and nodules on the head, face, trunk or limbs. There was a case with external skin symptoms. Histopathological features can be divided into three types: early juvenile xanthogranuloma (12.50%), the pathology showed a large number of histocytes infiltration, with scattered multinucleate giant cells, lymphocytes, and eosinophilic cells; mature juvenile xanthogranuloma (78.12%), the pathology showed typical foam cells, multinucleated giant cells and typical Touton giant cells;  transitional juvenile xanthogranuloma (9.38%), the pathology showed spindle shaped cells, histocytes and multinucleated giant cells. Immunohistochemical results were CD68 (+), CD1a (-), Langerin (-) and S-100 (-). Conclusion:The diagnosis of JXG can be made according to the typical skin lesion characteristics and pathological findings, while pathological examination is necessary to reduce the misdiagnosis rate.