皖南医学院第二附属医院抗菌药物专项整治前后抗菌药物的使用情况分析

目的调查皖南医学院第二附属医院抗菌药物专项整治前后抗菌药物的使用情况,以促进临床合理应用抗菌药物。方法调取皖南医学院第二附属医院2011、2015年抗菌药物的相关信息,对用药频度(DDDs)、用药金额、使用强度(AUD)、限定日费用(DDC)进行回顾性调查,并评价其合理性。结果抗菌药物专项整治后,抗菌药物的DDDs和用药金额均较整治前显著增加,DDDs和用药金额均增加较多的有大环内酯类,下降较多的为第4代头孢菌类;抗菌药物的AUD和DDC分别较整治前显著下降,下降较多的均为第4代头孢菌类。不合理用药现象较多为预防用药疗程长、选择药物不适宜、联合用药不适宜、无指征用药和预防用药时机不适宜,但整治后不合理率均较整治前明显降低。结论皖南医学院第二附属医院抗菌药物专项整治活动促使抗菌药物的AUD和不合理率明显下降,对不合理用药管制较有成效。

Analysis on use of antibacterial drugs before and after antibacterial treatment in the Second Affiliated Hospital of Wannan Medical College

Objective To investigate the use of antimicrobial drugs before and after antibacterial activity in the Second Affiliated Hospital of Wannan Medical College, and to promote the rational use of antibiotics in clinic. Methods The utilization data of antibacterial drugs in the Second Affiliated Hospital of Wannan Medical College in 2013 and 2015 was extracted, and frequency of drug use (DDDs), consumption sum, antibacterial use density (AUD), and defined daily cost (DDC) were analyzed statistically, and the rationality was evaluated. Results Compared with those before treatment, DDDs and consumption sum were increased significantly after antibacterial treatment. DDDs and consumption sum of the macrolides were increased more, while those of the fourth generation cephalosporin were decreased more. Compared with those before treatment, AUD and DDC were significantly decreased. And AUD and DDC of the fourth generation cephalosporin were decreased more. The main types of unreasonable medicine were prolonged prophylactic medication duration, inappropriate choice of medicine, inappropriate combination, no indication of medicine, and inappropriate prophylactic usage time, but the irrational rate after antibacterial treatment was lower than that before treatment. Conclusion The antibacterial treatment in the Second Affiliated Hospital of Wannan Medical College promotes the decline of AUD and the irrational rate, and it is more effective for the control of irrational drug use.