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| 在柱水解法自动化合成2-18F-2-脱氧-D-葡萄糖 | |
| 引用本文： | 罗磊,唐刚华,唐小兰. 在柱水解法自动化合成2-18F-2-脱氧-D-葡萄糖[J]. 中南大学学报(医学版), 2009, 34(11): 1151-1156 |
| 作者姓名： | 罗磊 唐刚华 唐小兰 |
| 作者单位： | 1.湖南省肿瘤医院PET-CT中心， 长沙 410013； 2.中山大学附属第一医院核医学科PET中心， 广州 510080； 3.华南农业大学理学院应用化学系，广州 510642 |
| 摘 要： | 目的：研究在柱水解法自动化合成2-18F-2-脱氧-D-葡萄糖(2-［18F］-fluoro-2-deoxy-D-glucose, 18F-FDG)。方法：采用在柱水解法和TRACERlab FXF-N自动化合成仪，以三氟甘露糖为前体，经亲核氟化、氢氧化钠在柱水解两步反应及SEP-PAK小柱分离纯化制备18F-FDG注射液。结果：18F-FDG总合成时间小于20 min，未校正放化产率大于60%，放化纯度大于99%。结论：在柱水解法合成18F-FDG注射液，操作简便，是很实用的18F-FDG生产方法。合成的18F-FDG注射液可用于临床PET显像研究。 |
| 关 键 词： | 2-18F-2-脱氧-D-葡萄糖；在柱水解法；自动化合成 |
| 收稿时间： | 2008-10-13 |
Automated synthesis of 2-[~(18)F]-fluoro-2-deoxy-D-glucose by on-column hydrolysis |
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| LUO Lei,TANG Ganghua,TANG Xiaolan. Automated synthesis of 2-[~(18)F]-fluoro-2-deoxy-D-glucose by on-column hydrolysis[J]. Journal of Central South University. Medical sciences, 2009, 34(11): 1151-1156 | |
| Authors: | LUO Lei TANG Ganghua TANG Xiaolan |
| Affiliation: | 1.PET-CT Centre, Hunan Tumour Hospital, Changsha 410013； 2.PET-CT Centre, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080； 3.Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou 510642, China |
| Abstract: | ObjectiveTo study automated synthesis of 2-［18F］-fluoro-2-deoxy-D-glucose (18F-FDG) via on-column hydrolysis. MethodsAutomated synthesis of 18F-FDG was performed by the on-column hydrolysis procedure in TRACERlab FXF-N synthesizer. 18F-FDG injection was obtained via nucleophilic fluorination of 1, 3, 4, 6-tetra-O-acetyl-2-O-trifluoromethanesulfony-β-D-mannopyranose as the precursor molecule with 18F-fluoride, hydrolysis of the 18F-labeled intermediate on SEP-PAK C18 cartridges with 2 mol/L NaOH solution, and purification and neutralization with SEP-PAK cartridges.ResultsThe uncorrected radiochemical yield of 18F-FDG was more than 60% within the total synthesis time shorter than 20 min. The radiochemical purity of 18F-FDG was above 99%. ConclusionOn-column hydrolysis is simple and practical for the automated synthesis of 18F-FDG. 18F-FDG injection produced by this procedure can be used in clinical PET imaging. |
| Keywords: | 2-［18F］-fluoro-2-deoxy-D-glucose；on-column hydrolysis；fully automated synthesis |
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