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Gadolinium‐Decorated Silica Microspheres as Redox‐Responsive MRI Probes for Applications in Cell Therapy Follow‐Up |
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| Authors: | Dr. Monica Muñoz Úbeda Dr. Fabio Carniato Dr. Valeria Catanzaro Sergio Padovan Dr. Cristina Grange Dr. Stefano Porta Dr. Carla Carrera Prof. Lorenzo Tei Dr. Giuseppe Digilio |
| Affiliation: | 1. Department of Science and Technologic Innovation, Università del Piemonte Orientale “Amedeo Avogadro”, Alessandria, Italy;2. Department of Molecular Biotechnology and Health Science & Center for Molecular Imaging, University of Turin, Torino, Italy;3. Institute for Biostructures and Bioimages (CNR) c/o, Molecular Biotechnology Center, Torino, Italy;4. Department of Medical Sciences, University of Turin, Torino, Italy |
| Abstract: | The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox‐responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd‐chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI. |
| Keywords: | cellular imaging gadolinium magnetic resonance imaging redox-responsive silica microspheres |
