Mild and Selective Catalytic Hydrogenation of the C=C Bond in α,β‐Unsaturated Carbonyl Compounds Using Supported Palladium Nanoparticles |
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| Authors: | Dr. Anuja Nagendiran Vlad Pascanu Dr. Antonio Bermejo Gómez Greco González Miera Dr. Cheuk‐Wai Tai Dr. Oscar Verho Prof. Dr. Belén Martín‐Matute Prof. Dr. Jan‐E. Bäckvall |
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| Affiliation: | 1. Department of Organic Chemistry and, Berzelii Centre EXSELENT on Porous Materials, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden;2. AstraZeneca Translational Science Center at Karolinska Institute, Stockholm, Sweden;3. Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden |
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| Abstract: | Chemoselective reduction of the C=C bond in a variety of α,β‐unsaturated carbonyl compounds using supported palladium nanoparticles is reported. Three different heterogeneous catalysts were compared using 1 atm of H2: 1) nano‐Pd on a metal–organic framework (MOF: Pd0‐MIL‐101‐NH2(Cr)), 2) nano‐Pd on a siliceous mesocellular foam (MCF: Pd0‐AmP‐MCF), and 3) commercially available palladium on carbon (Pd/C). Initial studies showed that the Pd@MOF and Pd@MCF nanocatalysts were superior in activity and selectivity compared to commercial Pd/C. Both Pd0‐MIL‐101‐NH2(Cr) and Pd0‐AmP‐MCF were capable of delivering the desired products in very short reaction times (10–90 min) with low loadings of Pd (0.5–1 mol %). Additionally, the two catalytic systems exhibited high recyclability and very low levels of metal leaching. |
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| Keywords: | heterogeneous catalysis mesocellular foam metal– organic framework palladium nanoparticles selective hydrogenation |
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