血脂代谢与胃癌发病风险相关性的病例对照研究

目的:探讨血脂代谢水平与胃癌发生发展的相关性.方法:选取2016年3月至2017年6月天津医科大学肿瘤医院诊治的1072例胃癌患者与同期1084例健康人群进行病例-对照研究,检测血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白(high-density ...

A case-control study of the correlation between lipid metabolism and gastric cancer risk

Objective:To investigate the correlation between lipid metabolism and gastric cancer.Methods:In total,1,072 patients with gastric cancer treated at Tianjin Medical University Cancer Institute and Hospital from March 2016 to June 2017 were enrolled,and 1,084 healthy subjects were included as controls.Using univariate and multivariate analyses,the correlation between lipid metabolism and gastric cancer risk was examined;furthermore,clinicopathological characteristics,including serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein(HDL),and low-density lipoprotein(LDL)levels,were assessed.Results:Serum TG and LDL levels were higher and HDL levels were lower in gastric cancer patients than in healthy controls.Furthermore,serum LDL levels were higher and HDL levels were lower in male gastric cancer patients than in healthy controls.Serum TG and LDL levels were higher and HDL levels were lower in female gastric cancer patients than in healthy controls(P<0.05).In all gastric cancer patients,HDL and LDL levels were significantly correlated with gastric cancer risk.Moreover,in male patients,HDL and LDL levels were significantly correlated with gastric cancer risk.In female patients,TG,HDL,and LDL levels were significantly associated with gastric cancer risk.Among gastric cancer patients,elevated TG and TC levels were more common in patients with distal gastric cancer and an early disease stage.Decreased HDL levels were more common in patients with little differentiated/undifferentiated gastric cancer.Among male patients,increased TG levels were more common in patients with an early disease stage.Decreased HDL levels were more common in patients with little differentiated/undifferentiated gastric cancer.Among female patients,elevated TC levels were more common in early-stage cancer patients.Conclusions:Serum lipid levels were higher in gastric cancer patients than in healthy controls,and they correlated with gastric cancer risk.However,as gastric cancer progresses owing to increased tumor nutrient uptake and patient's reduced nutritional status,serum lipid levels gradually decrease.