The Immunological Effect of 8-Methoxypsoralen and UVA Treatment on Murine T-Cell Leukemia |
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Authors: | Ting-Ying Cheng,Fung-Win Shen,Rong-Hwa Lin&dagger |
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Affiliation: | Graduate Institute of Microbiology;Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Taiwan, R.O.C. |
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Abstract: | Abstract— 8-Methoxypsoralen (8-MOP) plus long-wavelength UV radiation (UVA, 320–400 nm) have been used to treat various diseases such as cutaneous T-cell lymphoma, systemic scleroderma, rheumatoid arthritis and rejection of heart transplants. However, the immunological mechanism of this treatment remains unknown. In this report, we investigated the effect of 8-MOP/UVA on the modulation of the immunogenicity of a T-cell leukemia cell line (RL ♂l cells). The results demonstrated that the stimulator function of the in vitro 8-MOP/UVA-treated RL♂ cells was enhanced in both RL ♂1-specific allogeneic and syngeneic immune responses. Furthermore, the enhancement of the immunogenicity of the 8-MOP/UVA-treated RL♂ cells was found to be strongly associated with the increase of intercellular adhesion molecule-1 expression on these 8-MOP/UVA-treated tumor cells. Therefore, our findings suggested that the alteration of the expression of the immune-related cell surface molecules might be an important effect of 8-MOP/UVA treatment on the elevation of the immunogenicity of the 8-MOP/UVA-treated tumor cells. |
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