| 急性重症胰腺炎患者肠黏膜屏障功能的改变 |
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| 引用本文： | 杨廉泽,颜强,李学应,周忠信.急性重症胰腺炎患者肠黏膜屏障功能的改变[J].实用医学杂志,2005,21(9):903-906. |
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| 作者姓名： | 杨廉泽 颜强 李学应 周忠信 |
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| 作者单位： | 1. 529600,广东省阳春市人民医院普外科
2. 510089,广州市,中山大学附属第一医院外科 |
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| 摘 要： | 目的:探讨急性重症胰腺炎(SAP)的肠道黏膜屏障功能改变的机制,以期提高对SAP的治疗策略。方法:36例SAP患者入院当天采血检测二胺氧化酶(DAO)、内毒素(endotoxin,ET)、肿瘤坏死因子(TNF-α)、一氧化氮(NO)的浓度。并用带特殊电化学检测器的高压液相色谱法(HPLC)检测尿中乳果糖与甘露醇排泄率比值。以30名健康志愿者作为正常对照组。结果:同正常对照组相比较,SAP患者尿中乳果糖与甘露醇排泄率比值明显升高(P<0.01);血中ET、NO、TNFα、DAO的水平显著增加(P<0.01)。结论:急性重症胰腺炎患者的肠黏膜屏障受损,肠黏膜通透性增高。ET、NO、TNFα单独或协同参与肠黏膜屏障的损害。DAO升高提示肠道黏膜的完整性受到破坏。
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| 关 键 词： | 胰腺炎 急性坏死性 肠黏膜 内毒素 肿瘤坏死因子 二胺氧化酶 一氧化氮 |
The Analysis of the change about Intestinal Mucosal Barrier in Severe Acute Pancreatitis |
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| Yang Lian-ze,YAN Qiang,LI Xue-ying,ZHOU Zhong-xin.The Analysis of the change about Intestinal Mucosal Barrier in Severe Acute Pancreatitis[J].The Journal of Practical Medicine,2005,21(9):903-906. |
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| Authors: | Yang Lian-ze YAN Qiang LI Xue-ying ZHOU Zhong-xin |
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| Affiliation: | YANG Lian-ze,YAN Qiang,LI Xue-ying,ZHOU Zhong-xin.1,General Surgery Department,Yangchun Hospital,Yanchun City,Guangdong Province,529600,2,General Surgery Department,The first Affliated Hospital,Zhongshan University,Guangzhou,510089 |
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| Abstract: | Objective To explore the mechanism of the changes about the intestinal mucosal barrier in severe acute pancreatitis(SAP) in order to improve the treatment strategy.Methods Thirty-six patients diagnosed with SAP and 30 volunteers as the control group were enrolled into this research.The levels of serum tumor necrosis factor alpha(TNF-α),nitricoxide(NO),diamineoxidase(DAO) and plasma endotoxin(ET) were measured.The ratio of lactulose to mannitol(L/M) in urine was detected by HPLC with pulsed electroc hemical ... |
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| Keywords: | SAP Intestinal mucosa Endotoxins Tumor necrosis factor Nitricoxide Diamineoxidase |
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