用反相HPLC-电化学法研究人体内复方多巴片的生物利用

 用反相高效液相色谱－电化学（HPLC－ED）法对复方多巴进口片、国产甲片和国产乙片进行人体生物利用度研究，10名健康志愿者采用交叉、平行、对照法口服3种复方多巴片后，测定14h内不同时间的血药浓度。结果表明，国产片与进口片的相对生物利用度：左旋多巴国产甲片为99．40％，乙片为104．30％；卡比多巴国产甲片为99．92％，乙片为102．79％，国产片与进口片的药动学参数除左旋多巴中甲片的T_mar、乙片的C_mar、_1/2有非常显著性差异（P＜0．01）外，其它各项丰数均无显主性差异（P＞0．05）。

Bioavailability study of levodopa and carbidopa in ten healthy male volunteers by reversed-phase HPLC-ED

The bioavailability of levodopa-carbidopa tablets was investigated in ten healthyvoluteers after oral administration. Three kinds of levodopa-carbidopa tablets including sinemet(USA)and A Chinesetablet and B Chinese tablet were used to compare the bioavailability in bodywith cross ,parallel,contrast.The plasma of levodopa-carbidopa levels for 14 hours were deter-mined by HPLC-ED.Pharmacokinetic parameters were fitted with PKBP-N1 program on comput-er. The results show that the comparative bioavailability of A Chinese tablet was 99.40% of levodopa and 99.92% of carbidopa,and that of B Chinese tablet was 104,30%of levodopa and 102.79%of carbidopa.Excepting T_mar of levodopa in A Chinese and C_mar、T_1/2 of levodopa in B Chinese were significantly different (P<0.01)between foreign and Chinese tablet,there was no significant difference(P>0.05)between foreign and Chinese tablet on other pharmacokintic parameters.