The gene for the Lp(a)-specific glycoprotein is closely linked to the gene for plasminogen on chromosome 6 |
| |
| Authors: | Gisela Lindahl Elisabeth Gersdorf Han Jürgen Menzel Christoph Duba Hartmut Cleve Steve Humphries Gerd Utermann |
| |
| Affiliation: | (1) Charing Cross Sunley Research Centre, Lurgan Avenue, Hammersmith, W6 8LW London, UK;(2) Institut für Medizinische Biologie und Genetik der Universität, Schöpfstrasse 41, A-6020 Innsbruck, Austria;(3) Institut für Humangenetik und Anthropologie der Universität, Richard-Wagner-Strasse 10/5, D-8000 München 2, Federal Republic of Germany |
| |
| Abstract: | Summary We have studied the segregation of the Lp(a) glycoprotein phenotypes and of the plasminogen (PLG) polymorphism in three two-generation families. The inheritance of the Lp(a) gene was followed using the Lp(a) glycoprotein size polymorphism and that of the plasminogen gene, using protein and DNA polymorphisms. In the three families studied, no recombination was observed in 18 meioses. The lod score for linkage between the Lp(a) glycoprotein locus and the plasminogen locus in these families is greater than 5.0 at a recombination fraction of  =0. Our results show that the structural gene for the Lp(a) glycoprotein is closely linked to the gene for plasminogen on chromosome 6. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
